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TSSK4 testis specific serine kinase 4 [ Homo sapiens (human) ]

Gene ID: 283629, updated on 23-Nov-2021

Summary

Official Symbol
TSSK4provided by HGNC
Official Full Name
testis specific serine kinase 4provided by HGNC
Primary source
HGNC:HGNC:19825
See related
Ensembl:ENSG00000139908 MIM:610711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSK4; TSK-4; TSSK5; STK22E; C14orf20
Summary
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Expression
Broad expression in testis (RPKM 10.7), spleen (RPKM 1.5) and 18 other tissues See more
Orthologs
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Genomic context

See TSSK4 in Genome Data Viewer
Location:
14q12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24205524..24208362)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24674902..24677454)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene REC8 meiotic recombination protein Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene Sharpr-MPRA regulatory region 5945 Neighboring gene charged multivesicular body protein 4A Neighboring gene NEDD8-MDP1 readthrough Neighboring gene magnesium dependent phosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133264

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-threonine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in sperm flagellum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
testis-specific serine/threonine-protein kinase 4
Names
serine/threonine kinase 22E
serine/threonine-protein kinase 22E
NP_001171668.1
NP_001294996.1
NP_777604.2
XP_011534965.1
XP_024305310.1
XP_024305311.1
XP_024305312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184739.2NP_001171668.1  testis-specific serine/threonine-protein kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_001171668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK131042, AL136295, AY461663
    Consensus CDS
    CCDS53890.1
    UniProtKB/Swiss-Prot
    Q6SA08
    Related
    ENSP00000339179.5, ENST00000339917.10
    Conserved Domains (2) summary
    smart00220
    Location:25303
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14162
    Location:24303
    STKc_TSSK4-like; Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins
  2. NM_001308067.2NP_001294996.1  testis-specific serine/threonine-protein kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_001294996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site at an internal exon and uses an alternate 5'-terminal exon, which results in use of a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus and lacks an internal portion of the coding region compared to isoform 1.
    Source sequence(s)
    BC111088, BI825382, HY040551
    Consensus CDS
    CCDS76662.1
    UniProtKB/Swiss-Prot
    Q6SA08
    Related
    ENSP00000452054.1, ENST00000556621.5
    Conserved Domains (1) summary
    cl21453
    Location:1217
    PKc_like; Protein Kinases, catalytic domain
  3. NM_174944.4NP_777604.2  testis-specific serine/threonine-protein kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_777604.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) lacks 10 internal amino acids, compared to isoform 1.
    Source sequence(s)
    AK131042, AL136295, AY461663
    Consensus CDS
    CCDS9618.1
    UniProtKB/Swiss-Prot
    Q6SA08
    Related
    ENSP00000287913.6, ENST00000287913.10
    Conserved Domains (2) summary
    smart00220
    Location:25293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14162
    Location:24293
    STKc_TSSK4-like; Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24205524..24208362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449542.1XP_024305310.1  testis-specific serine/threonine-protein kinase 4 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:24278
    PKc_like; Protein Kinases, catalytic domain
  2. XM_024449543.1XP_024305311.1  testis-specific serine/threonine-protein kinase 4 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1202
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024449544.1XP_024305312.1  testis-specific serine/threonine-protein kinase 4 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1192
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011536663.2XP_011534965.1  testis-specific serine/threonine-protein kinase 4 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:1227
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1227
    PKc_like; Protein Kinases, catalytic domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    506674..509226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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