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TMED8 transmembrane p24 trafficking protein family member 8 [ Homo sapiens (human) ]

Gene ID: 283578, updated on 25-Jan-2022

Summary

Official Symbol
TMED8provided by HGNC
Official Full Name
transmembrane p24 trafficking protein family member 8provided by HGNC
Primary source
HGNC:HGNC:18633
See related
Ensembl:ENSG00000100580 AllianceGenome:HGNC:18633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM15B
Expression
Ubiquitous expression in lymph node (RPKM 7.4), thyroid (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See TMED8 in Genome Data Viewer
Location:
14q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (77335021..77377094, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77801364..77843437, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene protein O-mannosyltransferase 2 Neighboring gene glutathione S-transferase zeta 1 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene sterile alpha motif domain containing 15 Neighboring gene HNF1 motif-containing MPRA enhancer 277 Neighboring gene NADP dependent oxidoreductase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126559

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
protein TMED8
Names
family with sequence similarity 15, member B
transmembrane emp24 domain containing 8
transmembrane emp24 protein transport domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346131.2NP_001333060.1  protein TMED8 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC007954
  2. NM_001346133.2NP_001333062.1  protein TMED8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC007954
    UniProtKB/Swiss-Prot
    Q6PL24
    Conserved Domains (1) summary
    pfam13897
    Location:117256
    GOLD_2; Golgi-dynamics membrane-trafficking
  3. NM_001346134.1NP_001333063.1  protein TMED8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC007954
    UniProtKB/Swiss-Prot
    Q6PL24
    Conserved Domains (1) summary
    pfam13897
    Location:117256
    GOLD_2; Golgi-dynamics membrane-trafficking
  4. NM_213601.3NP_998766.1  protein TMED8 isoform b

    See identical proteins and their annotated locations for NP_998766.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC007954, BC101510
    Consensus CDS
    CCDS32125.1
    UniProtKB/Swiss-Prot
    Q6PL24
    Related
    ENSP00000216468.7, ENST00000216468.8
    Conserved Domains (1) summary
    pfam13897
    Location:185324
    GOLD_2; Golgi-dynamics membrane-trafficking

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    77335021..77377094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021224.1XP_016876713.1  protein TMED8 isoform X1

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