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ZDHHC22 zinc finger DHHC-type palmitoyltransferase 22 [ Homo sapiens (human) ]

Gene ID: 283576, updated on 22-Sep-2022

Summary

Official Symbol
ZDHHC22provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 22provided by HGNC
Primary source
HGNC:HGNC:20106
See related
Ensembl:ENSG00000177108 AllianceGenome:HGNC:20106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf59
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward brain (RPKM 10.2) See more
Orthologs
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Genomic context

See ZDHHC22 in Genome Data Viewer
Location:
14q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77131270..77142288, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71341038..71351579, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77597613..77608134, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903350 Neighboring gene CLOCK interacting pacemaker Neighboring gene family with sequence similarity 204 member D, pseudogene Neighboring gene transmembrane protein 63C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC22
Names
DHHC-22
putative palmitoyltransferase ZDHHC22
zinc finger DHHC domain-containing protein 22
zinc finger DHHC-type containing 22
zinc finger, DHHC domain containing 22
NP_001351101.1
NP_777636.2
XP_011534963.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364172.1NP_001351101.1  palmitoyltransferase ZDHHC22

    Status: VALIDATED

    Source sequence(s)
    AC007375
    Consensus CDS
    CCDS45140.1
    UniProtKB/Swiss-Prot
    Q149P4
    Conserved Domains (1) summary
    pfam01529
    Location:92218
    DHHC; DHHC palmitoyltransferase
  2. NM_174976.2NP_777636.2  palmitoyltransferase ZDHHC22

    See identical proteins and their annotated locations for NP_777636.2

    Status: VALIDATED

    Source sequence(s)
    AC007375, BC117676, DA496626
    Consensus CDS
    CCDS45140.1
    UniProtKB/Swiss-Prot
    Q149P4, Q8N966
    Related
    ENSP00000318222.4, ENST00000319374.4
    Conserved Domains (1) summary
    pfam01529
    Location:92218
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    77131270..77142288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536661.3XP_011534963.1  palmitoyltransferase ZDHHC22 isoform X1

    See identical proteins and their annotated locations for XP_011534963.1

    UniProtKB/Swiss-Prot
    Q149P4, Q8N966
    Conserved Domains (1) summary
    pfam01529
    Location:92218
    DHHC; DHHC palmitoyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    71341038..71351579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)