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GPR137C G protein-coupled receptor 137C [ Homo sapiens (human) ]

Gene ID: 283554, updated on 23-Nov-2021

Summary

Official Symbol
GPR137Cprovided by HGNC
Official Full Name
G protein-coupled receptor 137Cprovided by HGNC
Primary source
HGNC:HGNC:25445
See related
Ensembl:ENSG00000180998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM7SF1L2
Expression
Biased expression in brain (RPKM 7.8), testis (RPKM 1.4) and 8 other tissues See more
Orthologs
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Genomic context

See GPR137C in Genome Data Viewer
Location:
14q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52552836..52637713)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53019554..53104431)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene prostaglandin E receptor 2 Neighboring gene thioredoxin domain containing 16 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene proteasome 26S subunit, ATPase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762F0713

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integral membrane protein GPR137C
Names
G protein-coupled receptor TM7SF1L2
transmembrane 7 superfamily member 1-like 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099652.2NP_001093122.1  integral membrane protein GPR137C isoform 2

    See identical proteins and their annotated locations for NP_001093122.1

    Status: VALIDATED

    Source sequence(s)
    AK123953, AL133453, AL157971, AW470753, BM842962, BX647179
    Consensus CDS
    CCDS45106.1
    UniProtKB/Swiss-Prot
    Q8N3F9
    UniProtKB/TrEMBL
    B3KW22, Q6AWC7
    Related
    ENSP00000315106.6, ENST00000321662.11
  2. NM_001353361.2NP_001340290.1  integral membrane protein GPR137C isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL133453, AL157971, AL834372
    Related
    ENSP00000439165.2, ENST00000542169.6

RNA

  1. NR_148417.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL133453, AL157971

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52552836..52637713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449541.1XP_024305309.1  integral membrane protein GPR137C isoform X1

RNA

  1. XR_002957546.1 RNA Sequence

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