Format

Send to:

Choose Destination

GPR12 G protein-coupled receptor 12 [ Homo sapiens (human) ]

Gene ID: 2835, updated on 4-Jun-2020

Summary

Official Symbol
GPR12provided by HGNC
Official Full Name
G protein-coupled receptor 12provided by HGNC
Primary source
HGNC:HGNC:4466
See related
Ensembl:ENSG00000132975 MIM:600752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR12; GPCR21; PPP1R84
Expression
Biased expression in brain (RPKM 3.0) and salivary gland (RPKM 0.6) See more
Orthologs

Genomic context

See GPR12 in Genome Data Viewer
Location:
13q12.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (26755200..26760786, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27329337..27334922, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene WASP family member 3 Neighboring gene RPS3A pseudogene 44 Neighboring gene uncharacterized LOC107984597 Neighboring gene FGFR1 oncogene partner 2 pseudogene 1 Neighboring gene ribosomal protein S21 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18149, FLJ97704, MGC138349, MGC138351

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 12
Names
protein phosphatase 1, regulatory subunit 84

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005288.4NP_005279.1  G-protein coupled receptor 12

    See identical proteins and their annotated locations for NP_005279.1

    Status: VALIDATED

    Source sequence(s)
    AK290220, AL159978, AW015633
    Consensus CDS
    CCDS9319.1
    UniProtKB/Swiss-Prot
    P47775
    UniProtKB/TrEMBL
    A8K2F5
    Related
    ENSP00000384932.3, ENST00000405846.5
    Conserved Domains (1) summary
    cd15961
    Location:45312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    26755200..26760786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266360.3XP_005266417.1  G-protein coupled receptor 12 isoform X1

    See identical proteins and their annotated locations for XP_005266417.1

    UniProtKB/TrEMBL
    B4DG25
    Conserved Domains (1) summary
    pfam00001
    Location:1142
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Support Center