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TMPRSS12 transmembrane serine protease 12 [ Homo sapiens (human) ]

Gene ID: 283471, updated on 25-Jan-2022


Official Symbol
TMPRSS12provided by HGNC
Official Full Name
transmembrane serine protease 12provided by HGNC
Primary source
See related
Ensembl:ENSG00000186452 AllianceGenome:HGNC:28779
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein processing. Predicted to be located in acrosomal vesicle. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Restricted expression toward testis (RPKM 13.9) See more
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Genomic context

See TMPRSS12 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (50842926..50887884)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51236709..51281667)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene activating transcription factor 1 Neighboring gene RNA, 7SL, cytoplasmic 519, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.1615 Neighboring gene methyltransferase like 7A

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • MGC57341

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
transmembrane protease serine 12
testicular tissue protein Li 208
transmembrane (C-terminal) protease, serine 12
transmembrane protease, serine 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182559.3NP_872365.2  transmembrane protease serine 12 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008121, AC013244
    Consensus CDS
    ENSP00000381476.3, ENST00000398458.4
    Conserved Domains (1) summary
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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