U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KSR2 kinase suppressor of ras 2 [ Homo sapiens (human) ]

Gene ID: 283455, updated on 2-May-2024

Summary

Official Symbol
KSR2provided by HGNC
Official Full Name
kinase suppressor of ras 2provided by HGNC
Primary source
HGNC:HGNC:18610
See related
Ensembl:ENSG00000171435 MIM:610737; AllianceGenome:HGNC:18610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding activity; and protein kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 1.7), adrenal (RPKM 0.5) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KSR2 in Genome Data Viewer
Location:
12q24.22-q24.23
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (117453012..117968990, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (117440139..117956270, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117890817..118406795, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:117580597-117581796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117645205-117645705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117657550-117658106 Neighboring gene F-box protein 21 Neighboring gene MPRA-validated peak1985 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117670646-117670812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117674186-117674690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117674691-117675195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:117718941-117719440 Neighboring gene elongin C pseudogene 32 Neighboring gene nitric oxide synthase 1 Neighboring gene NOS1 1f and 1g alternate promoter region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117826376-117826876 Neighboring gene NOS1 1c alternate promoter Neighboring gene uncharacterized LOC105370012 Neighboring gene Sharpr-MPRA regulatory region 11046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118021615-118022115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118066793-118067293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118066292-118066792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118078225-118078724 Neighboring gene uncharacterized LOC105370011 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118274024-118274569 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:118284773-118285290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118312867-118313667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4919 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118442171-118442363 Neighboring gene MPRA-validated peak1990 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24987 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7106 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:118489679-118490878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4921 Neighboring gene uncharacterized LOC124903030 Neighboring gene replication factor C subunit 5 Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene V-set and immunoglobulin domain containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study link novel loci to endometriosis.
EBI GWAS Catalog
Genome-wide association study of biochemical traits in Korcula Island, Croatia.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP-kinase scaffold activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
kinase suppressor of Ras 2
NP_775869.4
XP_011536526.1
XP_011536527.1
XP_011536528.1
XP_011536531.1
XP_016874697.1
XP_016874698.1
XP_016874699.1
XP_054227814.1
XP_054227815.1
XP_054227816.1
XP_054227817.1
XP_054227818.1
XP_054227819.1
XP_054227820.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173598.6NP_775869.4  kinase suppressor of Ras 2

    Status: VALIDATED

    Source sequence(s)
    AC073864, AC079127, AC084291, AC092936
    Consensus CDS
    CCDS61250.2
    UniProtKB/Swiss-Prot
    A0PJT2, Q3B828, Q6VAB6, Q8N775
    Related
    ENSP00000339952.4, ENST00000339824.7
    Conserved Domains (3) summary
    cd14153
    Location:665934
    PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cl00040
    Location:408464
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    117453012..117968990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538224.4XP_011536526.1  kinase suppressor of Ras 2 isoform X1

    See identical proteins and their annotated locations for XP_011536526.1

    Conserved Domains (3) summary
    cd00029
    Location:413455
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14153
    Location:663932
    PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  2. XM_011538225.4XP_011536527.1  kinase suppressor of Ras 2 isoform X3

    See identical proteins and their annotated locations for XP_011536527.1

    Conserved Domains (2) summary
    cd00029
    Location:292334
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14153
    Location:544813
    PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
  3. XM_017019210.3XP_016874699.1  kinase suppressor of Ras 2 isoform X7

  4. XM_017019208.3XP_016874697.1  kinase suppressor of Ras 2 isoform X2

  5. XM_011538226.4XP_011536528.1  kinase suppressor of Ras 2 isoform X4

    Conserved Domains (3) summary
    cd00029
    Location:413455
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cl21453
    Location:665739
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011538229.4XP_011536531.1  kinase suppressor of Ras 2 isoform X6

    Conserved Domains (2) summary
    cd00029
    Location:413455
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  7. XM_017019209.3XP_016874698.1  kinase suppressor of Ras 2 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    117440139..117956270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371839.1XP_054227814.1  kinase suppressor of Ras 2 isoform X1

  2. XM_054371841.1XP_054227816.1  kinase suppressor of Ras 2 isoform X3

  3. XM_054371845.1XP_054227820.1  kinase suppressor of Ras 2 isoform X7

  4. XM_054371840.1XP_054227815.1  kinase suppressor of Ras 2 isoform X2

  5. XM_054371842.1XP_054227817.1  kinase suppressor of Ras 2 isoform X4

  6. XM_054371844.1XP_054227819.1  kinase suppressor of Ras 2 isoform X6

  7. XM_054371843.1XP_054227818.1  kinase suppressor of Ras 2 isoform X5