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KSR2 kinase suppressor of ras 2 [ Homo sapiens (human) ]

Gene ID: 283455, updated on 11-Jun-2021

Summary

Official Symbol
KSR2provided by HGNC
Official Full Name
kinase suppressor of ras 2provided by HGNC
Primary source
HGNC:HGNC:18610
See related
Ensembl:ENSG00000171435 MIM:610737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 1.7), adrenal (RPKM 0.5) and 7 other tissues See more
Orthologs
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Genomic context

See KSR2 in Genome Data Viewer
Location:
12q24.22-q24.23
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (117453012..117968990, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117890817..118406795, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 1 Neighboring gene NOS1 1f and 1g alternate promoter region Neighboring gene NOS1 1c alternate promoter Neighboring gene uncharacterized LOC105370012 Neighboring gene Sharpr-MPRA regulatory region 11046 Neighboring gene uncharacterized LOC105370011 Neighboring gene replication factor C subunit 5 Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene V-set and immunoglobulin domain containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide association study link novel loci to endometriosis.
GeneReviews: Not available
Genome-wide association study of biochemical traits in Korcula Island, Croatia.
GeneReviews: Not available
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinase suppressor of Ras 2
NP_775869.4
XP_011536526.1
XP_011536527.1
XP_011536528.1
XP_011536531.1
XP_016874697.1
XP_016874698.1
XP_016874699.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173598.6NP_775869.4  kinase suppressor of Ras 2

    Status: VALIDATED

    Source sequence(s)
    AC073864, AC079127, AC084291, AC092936
    Consensus CDS
    CCDS61250.1
    Related
    ENSP00000339952.4, ENST00000339824.7
    Conserved Domains (3) summary
    cd14153
    Location:665934
    PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cl00040
    Location:408464
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    117453012..117968990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538224.3XP_011536526.1  kinase suppressor of Ras 2 isoform X1

    See identical proteins and their annotated locations for XP_011536526.1

    Conserved Domains (3) summary
    cd00029
    Location:413455
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14153
    Location:663932
    PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  2. XM_011538225.3XP_011536527.1  kinase suppressor of Ras 2 isoform X3

    See identical proteins and their annotated locations for XP_011536527.1

    UniProtKB/Swiss-Prot
    Q6VAB6
    Conserved Domains (2) summary
    cd00029
    Location:292334
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14153
    Location:544813
    PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
  3. XM_017019210.2XP_016874699.1  kinase suppressor of Ras 2 isoform X7

  4. XM_017019208.2XP_016874697.1  kinase suppressor of Ras 2 isoform X2

  5. XM_011538226.3XP_011536528.1  kinase suppressor of Ras 2 isoform X4

    Conserved Domains (3) summary
    cd00029
    Location:413455
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cl21453
    Location:665739
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011538229.3XP_011536531.1  kinase suppressor of Ras 2 isoform X6

    Conserved Domains (2) summary
    cd00029
    Location:413455
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13543
    Location:24152
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  7. XM_017019209.2XP_016874698.1  kinase suppressor of Ras 2 isoform X5

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