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MYO1H myosin IH [ Homo sapiens (human) ]

Gene ID: 283446, updated on 22-Aug-2020

Summary

Official Symbol
MYO1Hprovided by HGNC
Official Full Name
myosin IHprovided by HGNC
Primary source
HGNC:HGNC:13879
See related
Ensembl:ENSG00000174527 MIM:614636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See MYO1H in Genome Data Viewer
Location:
12q24.11
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (109388277..109448371)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109826439..109886176)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene forkhead box N4 Neighboring gene long intergenic non-protein coding RNA 1486 Neighboring gene potassium channel tetramerization domain containing 10 Neighboring gene ubiquitin protein ligase E3B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • FLJ37587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ih
Names
myosin-1H
myosin-Ih

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101421.3NP_001094891.3  unconventional myosin-Ih

    Status: VALIDATED

    Source sequence(s)
    AC007570, AC012384, AK298093, BU616423, DB339279, DC359165, DC401393, DV080092, DV080385, DV080459, DV080460, DV080477
    Consensus CDS
    CCDS53826.1
    UniProtKB/TrEMBL
    B4DNW6
    Related
    ENSP00000444076.2, ENST00000431443.6
    Conserved Domains (3) summary
    smart00242
    Location:8689
    MYSc; Myosin. Large ATPases
    cd01378
    Location:26678
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:834997
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    109388277..109448371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538223.2XP_011536525.1  unconventional myosin-Ih isoform X1

    Conserved Domains (3) summary
    smart00242
    Location:8711
    MYSc; Myosin. Large ATPases
    cd01378
    Location:26700
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8561019
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_017019207.1XP_016874696.1  unconventional myosin-Ih isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173597.1: Suppressed sequence

    Description
    NM_173597.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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