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GAS2L3 growth arrest specific 2 like 3 [ Homo sapiens (human) ]

Gene ID: 283431, updated on 21-Dec-2019

Summary

Official Symbol
GAS2L3provided by HGNC
Official Full Name
growth arrest specific 2 like 3provided by HGNC
Primary source
HGNC:HGNC:27475
See related
Ensembl:ENSG00000139354 MIM:617224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G2L3
Expression
Broad expression in gall bladder (RPKM 2.2), colon (RPKM 1.8) and 23 other tissues See more
Orthologs

Genomic context

See GAS2L3 in Genome Data Viewer
Location:
12q23.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (100573668..100628288)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (100967446..101020657)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 member 8 Neighboring gene nuclear receptor subfamily 1 group H member 4 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A pseudogene 1 Neighboring gene anoctamin 4 Neighboring gene sorting nexin 5 pseudogene 2 Neighboring gene solute carrier family 5 member 8 Neighboring gene RNA, U6 small nuclear 768, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GAS2-like protein 3
Names
growth arrest-specific protein 2-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303130.2NP_001290059.1  GAS2-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_001290059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (a).
    Source sequence(s)
    AA398563, AC010209, AK315189
    Consensus CDS
    CCDS9079.1
    UniProtKB/Swiss-Prot
    Q86XJ1
    UniProtKB/TrEMBL
    A0A024RBF4
    Related
    ENSP00000266754.5, ENST00000266754.9
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  2. NM_001303131.1NP_001290060.1  GAS2-like protein 3 isoform b

    See identical proteins and their annotated locations for NP_001290060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AA398563, AC010209, AK095594, DA753921
    Consensus CDS
    CCDS76590.1
    UniProtKB/TrEMBL
    B3KTH9, G3V1N3
    Related
    ENSP00000442406.1, ENST00000537247.5
    Conserved Domains (2) summary
    pfam02187
    Location:110177
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:263
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  3. NM_001363672.2NP_001350601.1  GAS2-like protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC010200, AC010209
    Consensus CDS
    CCDS9079.1
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. NM_174942.3NP_777602.1  GAS2-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_777602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2 and 4 encode the same isoform (a).
    Source sequence(s)
    AA398563, AC010209, BC043366, BP872524
    Consensus CDS
    CCDS9079.1
    UniProtKB/Swiss-Prot
    Q86XJ1
    UniProtKB/TrEMBL
    A0A024RBF4
    Related
    ENSP00000448955.1, ENST00000547754.6
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    100573668..100628288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268804.3XP_005268861.1  GAS2-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005268861.1

    UniProtKB/Swiss-Prot
    Q86XJ1
    UniProtKB/TrEMBL
    A0A024RBF4
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  2. XM_017019206.1XP_016874695.1  GAS2-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q86XJ1
    UniProtKB/TrEMBL
    A0A024RBF4
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  3. XM_011538220.2XP_011536522.1  GAS2-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011536522.1

    UniProtKB/Swiss-Prot
    Q86XJ1
    UniProtKB/TrEMBL
    A0A024RBF4
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. XM_011538221.2XP_011536523.1  GAS2-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011536523.1

    UniProtKB/Swiss-Prot
    Q86XJ1
    UniProtKB/TrEMBL
    A0A024RBF4
    Related
    ENSP00000439672.1, ENST00000539410.2
    Conserved Domains (3) summary
    cd00014
    Location:49167
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:213281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl25496
    Location:309693
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
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