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ADGRD1 adhesion G protein-coupled receptor D1 [ Homo sapiens (human) ]

Gene ID: 283383, updated on 21-Dec-2019

Summary

Official Symbol
ADGRD1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor D1provided by HGNC
Primary source
HGNC:HGNC:19893
See related
Ensembl:ENSG00000111452 MIM:613639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR25; GPR133
Summary
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]
Expression
Broad expression in placenta (RPKM 7.4), lung (RPKM 6.8) and 20 other tissues See more
Orthologs

Genomic context

See ADGRD1 in Genome Data Viewer
Location:
12q24.33
Exon count:
30
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (130953907..131141469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (131438452..131626010)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1077, pseudogene Neighboring gene RAN, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 4789 Neighboring gene ADGRD1 antisense RNA 1 Neighboring gene uncharacterized LOC107984452 Neighboring gene long intergenic non-protein coding RNA 1257 Neighboring gene Sharpr-MPRA regulatory region 713

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
NHGRI GWA Catalog
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
NHGRI GWA Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Joint influence of small-effect genetic variants on human longevity.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of G protein-coupled receptor 133 (GPR133) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16770, MGC138512, MGC138514, DKFZp434B1272

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor D1
Names
G-protein coupled receptor 133
G-protein coupled receptor PGR25
probable G-protein coupled receptor 133

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330497.2NP_001317426.1  adhesion G-protein coupled receptor D1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC078925, AK131538, AL162032, AY532280, BC112309, BC143775, BQ028954, DA520615, EU523118
    Consensus CDS
    CCDS81753.1
    UniProtKB/Swiss-Prot
    Q6QNK2
    UniProtKB/TrEMBL
    Q9NSM3
    Related
    ENSP00000444425.1, ENST00000535015.5
  2. NM_198827.5NP_942122.2  adhesion G-protein coupled receptor D1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_942122.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC078925, AK131538, AL162032, AY532280, BC112307, BC112309, BQ028954, DA520615, EU523118
    Consensus CDS
    CCDS9272.1
    UniProtKB/Swiss-Prot
    Q6QNK2
    UniProtKB/TrEMBL
    Q9NSM3
    Related
    ENSP00000261654.5, ENST00000261654.10
    Conserved Domains (3) summary
    pfam01825
    Location:510550
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:138241
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:566802
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    130953907..131141469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538204.2XP_011536506.1  adhesion G-protein coupled receptor D1 isoform X1

    Conserved Domains (3) summary
    pfam01825
    Location:542582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:598834
    7tm_4; Olfactory receptor
  2. XM_011538206.2XP_011536508.1  adhesion G-protein coupled receptor D1 isoform X3

    Conserved Domains (3) summary
    pfam01825
    Location:542582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:583762
    7tm_4; Olfactory receptor
  3. XM_011538209.2XP_011536511.1  adhesion G-protein coupled receptor D1 isoform X7

    Conserved Domains (3) summary
    pfam01825
    Location:542582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:590666
    7tm_4; Olfactory receptor
  4. XM_011538205.2XP_011536507.1  adhesion G-protein coupled receptor D1 isoform X2

    Conserved Domains (3) summary
    pfam01825
    Location:482522
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:139213
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:538774
    7tm_4; Olfactory receptor
  5. XM_011538208.2XP_011536510.1  adhesion G-protein coupled receptor D1 isoform X6

    Conserved Domains (2) summary
    pfam01825
    Location:397437
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:453689
    7tm_4; Olfactory receptor
  6. XM_005253566.2XP_005253623.1  adhesion G-protein coupled receptor D1 isoform X4

    Conserved Domains (3) summary
    pfam01825
    Location:450490
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:107181
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:506742
    7tm_4; Olfactory receptor
  7. XM_011538207.2XP_011536509.1  adhesion G-protein coupled receptor D1 isoform X5

    Conserved Domains (3) summary
    pfam01825
    Location:542582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:598769
    7tm_4; Olfactory receptor
  8. XM_011538210.2XP_011536512.1  adhesion G-protein coupled receptor D1 isoform X8

    Conserved Domains (2) summary
    pfam01825
    Location:542582
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:170273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
  9. XM_011538211.2XP_011536513.1  adhesion G-protein coupled receptor D1 isoform X9

    Conserved Domains (2) summary
    pfam01825
    Location:206246
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:262498
    7tm_4; Olfactory receptor
  10. XM_011538212.2XP_011536514.1  adhesion G-protein coupled receptor D1 isoform X10

    Conserved Domains (2) summary
    pfam01825
    Location:132172
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:188424
    7tm_4; Olfactory receptor
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