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SPRYD4 SPRY domain containing 4 [ Homo sapiens (human) ]

Gene ID: 283377, updated on 4-Jul-2021

Summary

Official Symbol
SPRYD4provided by HGNC
Official Full Name
SPRY domain containing 4provided by HGNC
Primary source
HGNC:HGNC:27468
See related
Ensembl:ENSG00000176422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in liver (RPKM 19.9), kidney (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See SPRYD4 in Genome Data Viewer
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56468578..56479708)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56862362..56873492)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene timeless circadian regulator Neighboring gene major intrinsic protein of lens fiber Neighboring gene glutaminase 2 Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene RNA, U6 small nuclear 343, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
GeneReviews: Not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686N0877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SPRY domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207344.4NP_997227.1  SPRY domain-containing protein 4

    See identical proteins and their annotated locations for NP_997227.1

    Status: VALIDATED

    Source sequence(s)
    AC097104, AL832247, BX647957, DB041397
    Consensus CDS
    CCDS8920.1
    UniProtKB/Swiss-Prot
    Q8WW59
    Related
    ENSP00000338034.5, ENST00000338146.7
    Conserved Domains (1) summary
    cd12903
    Location:32200
    SPRY_PRY_SPRYD4; PRY/SPRY domain containing protein 4 (SPRYD4)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56468578..56479708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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