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SLC39A5 solute carrier family 39 member 5 [ Homo sapiens (human) ]

Gene ID: 283375, updated on 11-Jun-2021

Summary

Official Symbol
SLC39A5provided by HGNC
Official Full Name
solute carrier family 39 member 5provided by HGNC
Primary source
HGNC:HGNC:20502
See related
Ensembl:ENSG00000139540 MIM:608730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP5; MYP24; LZT-Hs7
Summary
The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Biased expression in duodenum (RPKM 78.5), small intestine (RPKM 76.3) and 4 other tissues See more
Orthologs
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Genomic context

See SLC39A5 in Genome Data Viewer
Location:
12q13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56230036..56237850)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56623835..56631630)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 41 Neighboring gene nucleic acid binding protein 2 Neighboring gene ankyrin repeat domain 52 Neighboring gene coenzyme Q10A Neighboring gene citrate synthase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34778

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G1 to G0 transition involved in cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc transporter ZIP5
Names
solute carrier family 39 (metal ion transporter), member 5
solute carrier family 39 (zinc transporter), member 5
zrt- and Irt-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034265.1 RefSeqGene

    Range
    5001..12811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135195.1NP_001128667.1  zinc transporter ZIP5 precursor

    See identical proteins and their annotated locations for NP_001128667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK172768, DA640935
    Consensus CDS
    CCDS8912.2
    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Related
    ENSP00000266980.4, ENST00000266980.8
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter
  2. NM_173596.3NP_775867.2  zinc transporter ZIP5 precursor

    See identical proteins and their annotated locations for NP_775867.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC073896
    Consensus CDS
    CCDS8912.2
    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Related
    ENSP00000405360.2, ENST00000454355.7
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56230036..56237850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538200.2XP_011536502.1  zinc transporter ZIP5 isoform X1

    See identical proteins and their annotated locations for XP_011536502.1

    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter
  2. XM_011538201.2XP_011536503.1  zinc transporter ZIP5 isoform X1

    See identical proteins and their annotated locations for XP_011536503.1

    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter
  3. XM_011538199.2XP_011536501.1  zinc transporter ZIP5 isoform X1

    See identical proteins and their annotated locations for XP_011536501.1

    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter
  4. XM_005268803.2XP_005268860.1  zinc transporter ZIP5 isoform X1

    See identical proteins and their annotated locations for XP_005268860.1

    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter
  5. XM_017019186.1XP_016874675.1  zinc transporter ZIP5 isoform X3

    Conserved Domains (1) summary
    pfam02535
    Location:79252
    Zip; ZIP Zinc transporter
  6. XM_017019187.2XP_016874676.1  zinc transporter ZIP5 isoform X3

    Conserved Domains (1) summary
    pfam02535
    Location:79252
    Zip; ZIP Zinc transporter
  7. XM_017019185.2XP_016874674.1  zinc transporter ZIP5 isoform X2

  8. XM_011538198.2XP_011536500.1  zinc transporter ZIP5 isoform X1

    See identical proteins and their annotated locations for XP_011536500.1

    UniProtKB/Swiss-Prot
    Q6ZMH5
    UniProtKB/TrEMBL
    A0A024RB24
    Conserved Domains (1) summary
    pfam02535
    Location:248504
    Zip; ZIP Zinc transporter

RNA

  1. XR_944520.1 RNA Sequence

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