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RASSF3 Ras association domain family member 3 [ Homo sapiens (human) ]

Gene ID: 283349, updated on 24-Nov-2020

Summary

Official Symbol
RASSF3provided by HGNC
Official Full Name
Ras association domain family member 3provided by HGNC
Primary source
HGNC:HGNC:14271
See related
Ensembl:ENSG00000153179 MIM:607019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RASSF5
Summary
The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]
Expression
Ubiquitous expression in spleen (RPKM 26.7), appendix (RPKM 26.2) and 25 other tissues See more
Orthologs

Genomic context

See RASSF3 in Genome Data Viewer
Location:
12q14.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (64610495..64697567)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (65004293..65091347)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984521 Neighboring gene uncharacterized LOC105369804 Neighboring gene microRNA 548c Neighboring gene microRNA 548z Neighboring gene glucosamine (N-acetyl)-6-sulfatase Neighboring gene TBC1 domain family member 30 Neighboring gene ribosomal protein L7 pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119194, MGC119195, MGC119197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ras association domain-containing protein 3
Names
Ras association (RalGDS/AF-6) domain family 3
Ras association (RalGDS/AF-6) domain family member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178169.4NP_835463.1  ras association domain-containing protein 3

    See identical proteins and their annotated locations for NP_835463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AC025262, AC078962, AY217662
    Consensus CDS
    CCDS8969.1
    UniProtKB/Swiss-Prot
    Q86WH2
    Related
    ENSP00000443021.1, ENST00000542104.6
    Conserved Domains (2) summary
    pfam16517
    Location:192231
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:79188
    UBQ; Ubiquitin-like proteins

RNA

  1. NR_040718.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA425154, AC025262, AC078962, AY217663

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    64610495..64697567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538195.2XP_011536497.1  ras association domain-containing protein 3 isoform X2

    Conserved Domains (2) summary
    pfam16517
    Location:180219
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:67176
    UBQ; Ubiquitin-like proteins
  2. XM_006719345.3XP_006719408.1  ras association domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    pfam16517
    Location:182221
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:69178
    UBQ; Ubiquitin-like proteins
  3. XM_017019182.1XP_016874671.1  ras association domain-containing protein 3 isoform X3

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