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CD163L1 CD163 molecule like 1 [ Homo sapiens (human) ]

Gene ID: 283316, updated on 2-Oct-2018

Summary

Official Symbol
CD163L1provided by HGNC
Official Full Name
CD163 molecule like 1provided by HGNC
Primary source
HGNC:HGNC:30375
See related
Ensembl:ENSG00000177675 MIM:606079; Vega:OTTHUMG00000168325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WC1; M160; CD163B; SCARI2
Summary
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in spleen (RPKM 7.7), small intestine (RPKM 4.5) and 14 other tissues See more
Orthologs

Genomic context

See CD163L1 in Genome Data Viewer
Location:
12p13.31
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (7320510..7444185, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7507556..7596778, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 5 Neighboring gene acyl-CoA synthetase medium chain family member 6 pseudogene Neighboring gene uncharacterized LOC101927882 Neighboring gene acyl-CoA synthetase medium chain family member 4 Neighboring gene M-phase phosphoprotein 8 pseudogene Neighboring gene CD163 molecule Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD163 molecule-like 1 (CD163L1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
scavenger receptor cysteine-rich type 1 protein M160
Names
CD163 antigen B
CD163 antigen-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297650.1NP_001284579.1  scavenger receptor cysteine-rich type 1 protein M160 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131205, AC131206, AC131207, AK303372, BQ024006, DC348327
    Consensus CDS
    CCDS73434.1
    UniProtKB/Swiss-Prot
    Q9NR16
    Related
    ENSP00000393474.2, OTTHUMP00000238591, ENST00000416109.2, OTTHUMT00000399330
    Conserved Domains (2) summary
    smart00202
    Location:10461146
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:10511146
    SRCR; Scavenger receptor cysteine-rich domain
  2. NM_174941.5NP_777601.2  scavenger receptor cysteine-rich type 1 protein M160 isoform 2 precursor

    See identical proteins and their annotated locations for NP_777601.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF264014, AK058038, BQ024006, DB145231, DC348327
    Consensus CDS
    CCDS8577.1
    UniProtKB/Swiss-Prot
    Q9NR16
    Related
    ENSP00000315945.3, OTTHUMP00000238590, ENST00000313599.7, OTTHUMT00000399329
    Conserved Domains (2) summary
    smart00202
    Location:10361136
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:10411136
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    7320510..7444185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520616.1XP_011518918.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X1

    UniProtKB/Swiss-Prot
    Q9NR16
    Conserved Domains (2) summary
    smart00202
    Location:10361136
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:10411136
    SRCR; Scavenger receptor cysteine-rich domain
  2. XM_011520617.2XP_011518919.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X2

    Conserved Domains (2) summary
    smart00202
    Location:10111111
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:10161111
    SRCR; Scavenger receptor cysteine-rich domain
  3. XM_011520620.1XP_011518922.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X4

    See identical proteins and their annotated locations for XP_011518922.1

    Conserved Domains (2) summary
    smart00202
    Location:765865
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:770865
    SRCR; Scavenger receptor cysteine-rich domain
  4. XM_011520619.1XP_011518921.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X4

    See identical proteins and their annotated locations for XP_011518921.1

    Conserved Domains (2) summary
    smart00202
    Location:765865
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:770865
    SRCR; Scavenger receptor cysteine-rich domain
  5. XM_011520618.3XP_011518920.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X3

    Conserved Domains (2) summary
    smart00202
    Location:797897
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:802897
    SRCR; Scavenger receptor cysteine-rich domain
  6. XM_011520621.3XP_011518923.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X5

    Conserved Domains (2) summary
    smart00202
    Location:349449
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:354449
    SRCR; Scavenger receptor cysteine-rich domain

RNA

  1. XR_931282.2 RNA Sequence

  2. XR_002957313.1 RNA Sequence

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