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CXCR3 C-X-C motif chemokine receptor 3 [ Homo sapiens (human) ]

Gene ID: 2833, updated on 13-Mar-2020

Summary

Official Symbol
CXCR3provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 3provided by HGNC
Primary source
HGNC:HGNC:4540
See related
Ensembl:ENSG00000186810 MIM:300574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
Summary
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Expression
Biased expression in lymph node (RPKM 6.3), spleen (RPKM 3.4) and 13 other tissues See more
Orthologs

Genomic context

See CXCR3 in Genome Data Viewer
Location:
Xq13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (71615913..71618515, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70835766..70838367, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene germ cell nuclear acidic peptidase Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene chromosome X open reading frame 49-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced upregulation of the CXCR3 and EMAP2 expression in human lung microvascular endothelial cells PubMed
env HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells PubMed
Nef nef HIV-1 Nef induces variable levels of CXCR3 downregulation in different cell types PubMed
nef Significant increases in neuronal cell death resulting from HIV-1 Nef-induced upregulation of IP-10 is reduced by an antibody directed against human CXCR3, suggesting an interaction of CXCR3 with Nef PubMed
Tat tat HIV-1 Tat can inhibit CXCR3-mediated functions by interfering with the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31 PubMed
Vif vif HIV-1 Vif upregulates the expression of chemokine (C-X-C motif) receptor 3 (CXCR3) in Vif-expression T cells PubMed
Vpu vpu HIV-1 Vpu downregulates the cell surface expression of chemokine (C-X-C motif) receptor 3 (CXCR3, CD183) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 3
Names
G protein-coupled receptor 9
IP-10 receptor
Mig receptor
chemokine (C-X-C motif) receptor 3
chemokine receptor 3
interferon-inducible protein 10 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029076.1 RefSeqGene

    Range
    5007..7599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142797.2NP_001136269.1  C-X-C chemokine receptor type 3 isoform 2

    See identical proteins and their annotated locations for NP_001136269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).
    Source sequence(s)
    AF469635, X95876
    Consensus CDS
    CCDS48135.1
    UniProtKB/Swiss-Prot
    P49682
    Related
    ENSP00000362795.4, ENST00000373691.4
    Conserved Domains (1) summary
    cd15180
    Location:101376
    7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001504.2NP_001495.1  C-X-C chemokine receptor type 3 isoform 1

    See identical proteins and their annotated locations for NP_001495.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as CXCR3-A). This isoform functions as a receptor for chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
    Source sequence(s)
    X95876
    Consensus CDS
    CCDS14416.1
    UniProtKB/Swiss-Prot
    P49682
    Related
    ENSP00000362797.3, ENST00000373693.4
    Conserved Domains (1) summary
    cd15180
    Location:54329
    7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    71615913..71618515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029436.1XP_016884925.1  C-X-C chemokine receptor type 3 isoform X4

  2. XM_005262257.3XP_005262314.1  C-X-C chemokine receptor type 3 isoform X3

    Conserved Domains (1) summary
    pfam00001
    Location:84218
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_005262256.3XP_005262313.1  C-X-C chemokine receptor type 3 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:84328
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_017029435.1XP_016884924.1  C-X-C chemokine receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    P49682
    Conserved Domains (1) summary
    cd15180
    Location:101376
    7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
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