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OR10A4 olfactory receptor family 10 subfamily A member 4 [ Homo sapiens (human) ]

Gene ID: 283297, updated on 2-Nov-2024

Summary

Official Symbol
OR10A4provided by HGNC
Official Full Name
olfactory receptor family 10 subfamily A member 4provided by HGNC
Primary source
HGNC:HGNC:15130
See related
Ensembl:ENSG00000170782 AllianceGenome:HGNC:15130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JCG5; OR10A4P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR10A4 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6876625..6877619)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6935004..6935998)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6897856..6898850)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 5 Neighboring gene olfactory receptor family 10 subfamily A member 2 Neighboring gene uncharacterized LOC107984019 Neighboring gene olfactory receptor family 2 subfamily D member 2 Neighboring gene olfactory receptor family 2 subfamily D member 3

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 10A4
Names
hP2 olfactory receptor
olfactory receptor OR11-87
olfactory receptor, family 10, subfamily A, member 4 pseudogene
olfactory receptor-like protein JCG5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207186.2NP_997069.2  olfactory receptor 10A4

    See identical proteins and their annotated locations for NP_997069.2

    Status: VALIDATED

    Source sequence(s)
    AC087280
    Consensus CDS
    CCDS7774.1
    UniProtKB/Swiss-Prot
    B2RNP5, B9EH36, Q96R20, Q9H209
    UniProtKB/TrEMBL
    A0A126GWA1
    Related
    ENSP00000369157.2, ENST00000379829.2
    Conserved Domains (2) summary
    pfam00001
    Location:42291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35306
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6876625..6877619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6935004..6935998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)