Format

Send to:

Choose Destination

TMEM80 transmembrane protein 80 [ Homo sapiens (human) ]

Gene ID: 283232, updated on 23-Nov-2021

Summary

Official Symbol
TMEM80provided by HGNC
Official Full Name
transmembrane protein 80provided by HGNC
Primary source
HGNC:HGNC:27453
See related
Ensembl:ENSG00000177042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 7.9), prostate (RPKM 7.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM80 in Genome Data Viewer
Location:
11p15.5
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (695585..705028)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (695639..705028)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretin Neighboring gene dopamine receptor D4 Neighboring gene DEAF1 transcription factor Neighboring gene EPS8 like 2 Neighboring gene uncharacterized LOC105376509

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38216, FLJ55823

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042463.3NP_001035928.3  transmembrane protein 80 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 5. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 5.
    Source sequence(s)
    AC131934
    Consensus CDS
    CCDS41587.2
    Related
    ENSP00000380646.4, ENST00000397510.9
    Conserved Domains (1) summary
    pfam09799
    Location:24127
    Transmemb_17; Predicted membrane protein
  2. NM_001276253.2NP_001263182.2  transmembrane protein 80 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region compared to variant 5. It encodes isoform 4, which has a distinct C-terminus and is shorter, compared to isoform 5.
    Source sequence(s)
    AC131934
    Consensus CDS
    CCDS73231.1
    Related
    ENSP00000476563.3, ENST00000608174.6
  3. NM_001276274.2NP_001263203.2  transmembrane protein 80 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC131934
    Related
    ENSP00000436199.3, ENST00000526170.6
    Conserved Domains (1) summary
    pfam09799
    Location:24127
    Transmemb_17; Predicted membrane protein
  4. NM_001384408.1NP_001371337.1  transmembrane protein 80 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131934
    Conserved Domains (1) summary
    pfam09799
    Location:41144
    Transmemb_17; Predicted membrane protein
  5. NM_174940.4NP_777600.4  transmembrane protein 80 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region compared to variant 5. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 5.
    Source sequence(s)
    AC131934
    Related
    ENSP00000380648.4, ENST00000397512.8
    Conserved Domains (1) summary
    pfam09799
    Location:4107
    Transmemb_17; Predicted membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    695585..705028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718206.3XP_006718269.3  transmembrane protein 80 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042464.1: Suppressed sequence

    Description
    NM_001042464.1: This RefSeq was temporarily suppressed because sufficient data to support this transcript currently does not exist.
Support Center