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KCTD21 potassium channel tetramerization domain containing 21 [ Homo sapiens (human) ]

Gene ID: 283219, updated on 8-Feb-2025

Summary

Official Symbol
KCTD21provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 21provided by HGNC
Primary source
HGNC:HGNC:27452
See related
Ensembl:ENSG00000188997 MIM:618790; AllianceGenome:HGNC:27452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCASH2
Summary
Enables cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Feb 2025]
Expression
Ubiquitous expression in thyroid (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See KCTD21 in Genome Data Viewer
Location:
11q14.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (78171249..78188626, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (78104491..78121889, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77882295..77899672, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369401 Neighboring gene Sharpr-MPRA regulatory region 11448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77840054-77840872 Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77851405-77852115 Neighboring gene RNA, U6 small nuclear 126, pseudogene Neighboring gene KCTD21 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77884885-77885386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77890493-77890992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77921405-77922031 Neighboring gene ubiquitin specific peptidase 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5318 Neighboring gene GRB2 associated binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 2371 Neighboring gene uncharacterized LOC105369402

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD21
Names
potassium channel tetramerisation domain containing 21
potassium channel tetramerization domain-containing protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029859.3NP_001025030.1  BTB/POZ domain-containing protein KCTD21

    See identical proteins and their annotated locations for NP_001025030.1

    Status: VALIDATED

    Source sequence(s)
    AK095233, DC342183
    Consensus CDS
    CCDS31645.1
    UniProtKB/Swiss-Prot
    B4DTR0, Q4G0X4
    Related
    ENSP00000339340.3, ENST00000340067.4
    Conserved Domains (1) summary
    cd18395
    Location:3100
    BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    78171249..78188626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718517.3XP_006718580.1  BTB/POZ domain-containing protein KCTD21 isoform X1

    See identical proteins and their annotated locations for XP_006718580.1

    UniProtKB/Swiss-Prot
    B4DTR0, Q4G0X4
    Conserved Domains (1) summary
    cd18395
    Location:3100
    BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)
  2. XM_047426803.1XP_047282759.1  BTB/POZ domain-containing protein KCTD21 isoform X2

  3. XM_006718518.4XP_006718581.1  BTB/POZ domain-containing protein KCTD21 isoform X1

    See identical proteins and their annotated locations for XP_006718581.1

    UniProtKB/Swiss-Prot
    B4DTR0, Q4G0X4
    Conserved Domains (1) summary
    cd18395
    Location:3100
    BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    78104491..78121889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368483.1XP_054224458.1  BTB/POZ domain-containing protein KCTD21 isoform X1

    UniProtKB/Swiss-Prot
    B4DTR0, Q4G0X4
  2. XM_054368482.1XP_054224457.1  BTB/POZ domain-containing protein KCTD21 isoform X2

  3. XM_054368481.1XP_054224456.1  BTB/POZ domain-containing protein KCTD21 isoform X1

    UniProtKB/Swiss-Prot
    B4DTR0, Q4G0X4