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KLHL35 kelch like family member 35 [ Homo sapiens (human) ]

Gene ID: 283212, updated on 13-Mar-2020

Summary

Official Symbol
KLHL35provided by HGNC
Official Full Name
kelch like family member 35provided by HGNC
Primary source
HGNC:HGNC:26597
See related
Ensembl:ENSG00000149243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.5), brain (RPKM 0.7) and 6 other tissues See more
Orthologs

Genomic context

See KLHL35 in Genome Data Viewer
Location:
11q13.4
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (75422394..75430629, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75133438..75141674, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene ribosomal protein S3 Neighboring gene Sharpr-MPRA regulatory regions 6111 and 12908 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene uncharacterized LOC105369389 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4348

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 26597, FLJ33790, DKFZp566C0546

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
kelch-like protein 35
Names
kelch-like 35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039548.2NP_001034637.2  kelch-like protein 35

    See identical proteins and their annotated locations for NP_001034637.2

    Status: VALIDATED

    Source sequence(s)
    AP000744, BC042952
    Consensus CDS
    CCDS44685.2
    UniProtKB/Swiss-Prot
    Q6PF15
    Related
    ENSP00000438526.1, ENST00000539798.1
    Conserved Domains (6) summary
    smart00612
    Location:395441
    Kelch; Kelch domain
    smart00225
    Location:4276
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:156255
    BACK; BTB And C-terminal Kelch
    sd00038
    Location:340380
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:3170
    BTB; BTB/POZ domain
    pfam01344
    Location:432470
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    75422394..75430629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173583.1: Suppressed sequence

    Description
    NM_173583.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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