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CDH20 cadherin 20 [ Homo sapiens (human) ]

Gene ID: 28316, updated on 23-Nov-2021

Summary

Official Symbol
CDH20provided by HGNC
Official Full Name
cadherin 20provided by HGNC
Primary source
HGNC:HGNC:1760
See related
Ensembl:ENSG00000101542 MIM:605807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cdh7; CDH7L3
Summary
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 10.7) and fat (RPKM 4.1) See more
Orthologs
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Genomic context

See CDH20 in Genome Data Viewer
Location:
18q21.33
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (61333430..61555779)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (59000663..59223012)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 14 effector protein pseudogene Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 31 Neighboring gene RNA, U6 small nuclear 116, pseudogene Neighboring gene ribosomal protein L30 pseudogene 14 Neighboring gene uncharacterized LOC105372157 Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cadherin-20
Names
cadherin 20, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031891.4NP_114097.2  cadherin-20 preproprotein

    See identical proteins and their annotated locations for NP_114097.2

    Status: REVIEWED

    Source sequence(s)
    AC006203, AC025656, AC090409
    Consensus CDS
    CCDS11977.1
    UniProtKB/Swiss-Prot
    Q9HBT6
    UniProtKB/TrEMBL
    A8K2C5, Q8N9J3
    Related
    ENSP00000262717.3, ENST00000262717.9
    Conserved Domains (3) summary
    cd11304
    Location:394490
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:85163
    CA; Cadherin repeats
    pfam01049
    Location:643794
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    61333430..61555779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451165.1XP_024306933.1  cadherin-20 isoform X1

    Conserved Domains (3) summary
    cd11304
    Location:394490
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:85163
    CA; Cadherin repeats
    pfam01049
    Location:643794
    Cadherin_C; Cadherin cytoplasmic region

RNA

  1. XR_001753187.1 RNA Sequence

  2. XR_001753186.1 RNA Sequence

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