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BCL9L BCL9 like [ Homo sapiens (human) ]

Gene ID: 283149, updated on 23-Nov-2021

Summary

Official Symbol
BCL9Lprovided by HGNC
Official Full Name
BCL9 likeprovided by HGNC
Primary source
HGNC:HGNC:23688
See related
Ensembl:ENSG00000186174 MIM:609004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B9L; BCL9-2; DLNB11
Expression
Ubiquitous expression in placenta (RPKM 7.2), appendix (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See BCL9L in Genome Data Viewer
Location:
11q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118896136..118926071, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118766845..118796635, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 6 Neighboring gene SET pseudogene 16 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene microRNA 4492 Neighboring gene RNA, 7SL, cytoplasmic 688, pseudogene Neighboring gene uroplakin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
B-cell CLL/lymphoma 9-like protein
Names
B cell CLL/lymphoma 9 like
B-cell lymphoma 9-like protein
BCL9-like protein
nuclear co-factor of beta-catenin signalling
protein BCL9-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378213.1NP_001365142.1  B-cell CLL/lymphoma 9-like protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP004609
    Related
    ENSP00000507778.1, ENST00000683865.1
    Conserved Domains (2) summary
    PHA03247
    Location:9461378
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:398432
    BCL9; B-cell lymphoma 9 protein
  2. NM_001378214.1NP_001365143.1  B-cell CLL/lymphoma 9-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AP004609
    Conserved Domains (2) summary
    PHA03247
    Location:9091341
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:361395
    BCL9; B-cell lymphoma 9 protein
  3. NM_182557.4NP_872363.1  B-cell CLL/lymphoma 9-like protein isoform a

    See identical proteins and their annotated locations for NP_872363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP004609
    Consensus CDS
    CCDS8403.1
    UniProtKB/Swiss-Prot
    Q86UU0
    Related
    ENSP00000335320.3, ENST00000334801.7
    Conserved Domains (2) summary
    PHA03247
    Location:9461378
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:398432
    BCL9; B-cell lymphoma 9 protein

RNA

  1. NR_165445.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP004609

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118896136..118926071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718815.3XP_006718878.1  B-cell CLL/lymphoma 9-like protein isoform X5

    See identical proteins and their annotated locations for XP_006718878.1

    UniProtKB/Swiss-Prot
    Q86UU0
    Conserved Domains (2) summary
    PHA03247
    Location:9461378
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:398432
    BCL9; B-cell lymphoma 9 protein
  2. XM_017017572.1XP_016873061.1  B-cell CLL/lymphoma 9-like protein isoform X1

  3. XM_005271513.3XP_005271570.1  B-cell CLL/lymphoma 9-like protein isoform X6

    See identical proteins and their annotated locations for XP_005271570.1

    UniProtKB/TrEMBL
    A0A087WZX0
    Related
    ENSP00000482938.1, ENST00000526143.2
    Conserved Domains (2) summary
    PHA03247
    Location:9091341
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:361395
    BCL9; B-cell lymphoma 9 protein
  4. XM_017017574.1XP_016873063.1  B-cell CLL/lymphoma 9-like protein isoform X4

  5. XM_017017573.1XP_016873062.1  B-cell CLL/lymphoma 9-like protein isoform X2

  6. XM_011542756.2XP_011541058.1  B-cell CLL/lymphoma 9-like protein isoform X3

    Conserved Domains (1) summary
    pfam11502
    Location:413447
    BCL9; B-cell lymphoma 9 protein
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