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NEAT1 nuclear paraspeckle assembly transcript 1 [ Homo sapiens (human) ]

Gene ID: 283131, updated on 5-Jul-2020

Summary

Official Symbol
NEAT1provided by HGNC
Official Full Name
nuclear paraspeckle assembly transcript 1provided by HGNC
Primary source
HGNC:HGNC:30815
See related
Ensembl:ENSG00000245532 MIM:612769
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VINC; TncRNA; LINC00084; NCRNA00084
Summary
This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]
Orthologs

Genomic context

See NEAT1 in Genome Data Viewer
Location:
11q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65422798..65445540)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65190269..65194003)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr11.3233 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3235 Neighboring gene uncharacterized LOC107984338 Neighboring gene microRNA 612 Neighboring gene FAU, ubiquitin like and ribosomal protein S30 fusion pseudogene Neighboring gene NEAT1-MALAT1 intergenic CAGE-defined mid-level expression enhancer

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • MENepsilon/beta
  • long intergenic non-protein coding RNA 84
  • nuclear enriched abundant transcript 1
  • nuclear paraspeckle assembly transcript 1 (non-protein coding)
  • trophoblast MHC class II suppressor
  • trophoblast-derived noncoding RNA
  • virus inducible non-coding RNA

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RISC complex binding IDA
Inferred from Direct Assay
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synoviocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
paraspeckles IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028272.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant has a shorter 3' end compared to the MENbeta variant. This results in a shorter transcript, known as MENepsilon or NEAT1_1. The 3' end is stabilized with a canonical poly(A) tail.
    Source sequence(s)
    AI590745, EF177379
  2. NR_131012.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longer transcript, known as MENbeta or NEAT1_2. The 3' end is stabilized by a triple helical structure.
    Source sequence(s)
    GQ859162
    Related
    ENST00000501122.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65422798..65445540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_002802.2: Suppressed sequence

    Description
    NR_002802.2: This RefSeq was permanently suppressed because it does not represent the functional transcript.
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