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OR52Z1P olfactory receptor family 52 subfamily Z member 1 pseudogene [ Homo sapiens (human) ]

Gene ID: 283110, updated on 8-Mar-2025

Summary

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Official Symbol
OR52Z1Pprovided by HGNC
Official Full Name
olfactory receptor family 52 subfamily Z member 1 pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:19596
See related
Ensembl:ENSG00000176748 AllianceGenome:HGNC:19596
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR52Z1
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Orthologs
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Genomic context

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See OR52Z1P in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5177714..5178664, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5237038..5237993, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5198944..5199894, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hereditary persistence of fetal hemoglobin-1 and -2 3' breakpoint enhancers Neighboring gene olfactory receptor family 52 subfamily A member 1 Neighboring gene hereditary persistence of fetal hemoglobin-6 3' breakpoint enhancer Neighboring gene olfactory receptor family 51 subfamily A member 1 pseudogene Neighboring gene hereditary persistence of fetal hemoglobin-3 3' breakpoint enhancer Neighboring gene olfactory receptor family 51 subfamily V member 1 Neighboring gene beta-globin 3' hypersensitive site 1 Neighboring gene origin of replication at HBB Neighboring gene ReSE screen-validated silencer GRCh37_chr11:5244549-5244757 Neighboring gene beta-globin gene 3' regulatory region Neighboring gene HBB recombination region Neighboring gene hemoglobin subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic elucidation of human hyperosmia to isovaleric acid. Menashe I, et al. PLoS Biol, 2007 Oct 30. PMID 17973576, Free PMC Article
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Bulger M, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121057, Free PMC Article
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
  4. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Other Names

  • Olfactory receptor 52Z1
  • odorant receptor HOR3'beta2
  • olfactory receptor, family 52, subfamily Z, member 1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_172914.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129505
    Related
    ENST00000510471.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    5177714..5178664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    5237038..5237993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_004304.6: Suppressed sequence

    Description
    NG_004304.6: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NG_071173.1: Suppressed sequence

    Description
    NG_071173.1: This RefSeq was removed because it is now thought that this gene is a transcribed pseudogene.

  3. NM_001348257.1: Suppressed sequence

    Description
    NM_001348257.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C646.2 GenPept UniProtKB/Swiss-Prot:P0C646

Gene LinkOut

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Research Materials