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CSNK2A3 casein kinase 2 alpha 3 [ Homo sapiens (human) ]

Gene ID: 283106, updated on 5-Jan-2022

Summary

Official Symbol
CSNK2A3provided by HGNC
Official Full Name
casein kinase 2 alpha 3provided by HGNC
Primary source
HGNC:HGNC:2458
See related
Ensembl:ENSG00000254598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNK2A1P
Summary
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]
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Genomic context

See CSNK2A3 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (11351942..11353250, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11373489..11374797, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2752 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 22 Neighboring gene MT-ND5 pseudogene 21 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 18 Neighboring gene Sharpr-MPRA regulatory region 8932 Neighboring gene uncharacterized LOC107983976

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
casein kinase II subunit alpha 3
Names
casein kinase 2, alpha 1 polypeptide pseudogene
casein kinase 2, alpha 3 polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256686.2NP_001243615.1  casein kinase II subunit alpha 3

    See identical proteins and their annotated locations for NP_001243615.1

    Status: VALIDATED

    Source sequence(s)
    AC023946
    Consensus CDS
    CCDS59224.1
    UniProtKB/Swiss-Prot
    Q8NEV1
    Related
    ENSP00000473553.1, ENST00000528848.3
    Conserved Domains (3) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam00069
    Location:39324
    Pkinase; Protein kinase domain
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    11351942..11353250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_002207.1: Suppressed sequence

    Description
    NR_002207.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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