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MKX mohawk homeobox [ Homo sapiens (human) ]

Gene ID: 283078, updated on 4-Jun-2020

Summary

Official Symbol
MKXprovided by HGNC
Official Full Name
mohawk homeoboxprovided by HGNC
Primary source
HGNC:HGNC:23729
See related
Ensembl:ENSG00000150051 MIM:601332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFRX; IRXL1; C10orf48
Summary
The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]
Expression
Biased expression in prostate (RPKM 5.8), ovary (RPKM 4.5) and 13 other tissues See more
Orthologs

Genomic context

See MKX in Genome Data Viewer
Location:
10p12.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (27672874..27745819, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (27961803..28034778, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RAB18, member RAS oncogene family Neighboring gene long intergenic non-protein coding RNA 2680 Neighboring gene MKX antisense RNA 1 Neighboring gene RN7SK pseudogene 132 Neighboring gene armadillo repeat containing 4 Neighboring gene ribosomal protein L36a pseudogene 55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39616

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle organ development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Mohawk
Names
Iroquois family related homeodomain protein
iroquois homeobox protein-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029181.1 RefSeqGene

    Range
    5031..77976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242702.2NP_001229631.1  homeobox protein Mohawk

    See identical proteins and their annotated locations for NP_001229631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC024606, AK125339, AW020078, BC036207
    Consensus CDS
    CCDS7156.1
    UniProtKB/Swiss-Prot
    Q8IYA7
    Related
    ENSP00000364946.4, ENST00000375790.9
    Conserved Domains (1) summary
    pfam05920
    Location:88127
    Homeobox_KN; Homeobox KN domain
  2. NM_173576.3NP_775847.2  homeobox protein Mohawk

    See identical proteins and their annotated locations for NP_775847.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC024606, AW020078, BC036207, DB285243
    Consensus CDS
    CCDS7156.1
    UniProtKB/Swiss-Prot
    Q8IYA7
    Related
    ENSP00000400896.1, ENST00000419761.6
    Conserved Domains (1) summary
    pfam05920
    Location:88127
    Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    27672874..27745819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016105.1XP_016871594.1  homeobox protein Mohawk isoform X1

    UniProtKB/Swiss-Prot
    Q8IYA7
    Conserved Domains (1) summary
    pfam05920
    Location:88127
    Homeobox_KN; Homeobox KN domain
  2. XM_017016106.1XP_016871595.1  homeobox protein Mohawk isoform X1

    UniProtKB/Swiss-Prot
    Q8IYA7
    Conserved Domains (1) summary
    pfam05920
    Location:88127
    Homeobox_KN; Homeobox KN domain
  3. XM_017016108.1XP_016871597.1  homeobox protein Mohawk isoform X3

    Conserved Domains (1) summary
    pfam05920
    Location:88127
    Homeobox_KN; Homeobox KN domain
  4. XM_017016107.1XP_016871596.1  homeobox protein Mohawk isoform X2

    Related
    ENSP00000452751.1, ENST00000460919.2
    Conserved Domains (1) summary
    pfam05920
    Location:88127
    Homeobox_KN; Homeobox KN domain
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