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GPR6 G protein-coupled receptor 6 [ Homo sapiens (human) ]

Gene ID: 2830, updated on 22-Sep-2022

Summary

Official Symbol
GPR6provided by HGNC
Official Full Name
G protein-coupled receptor 6provided by HGNC
Primary source
HGNC:HGNC:4515
See related
Ensembl:ENSG00000146360 MIM:600553; AllianceGenome:HGNC:4515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GPR6 in Genome Data Viewer
Location:
6q21
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (109978311..109980720)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111156757..111159166)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110299514..110301923)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ZBTB24 divergent transcript Neighboring gene adenylate kinase 9 Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene uncharacterized LOC107986631 Neighboring gene WASP family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ59257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sphingosine-1-phosphate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 6
Names
sphingosine 1-phosphate receptor GPR6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286099.2NP_001273028.1  G-protein coupled receptor 6 isoform a

    See identical proteins and their annotated locations for NP_001273028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and enocdes the longer isoform (a).
    Source sequence(s)
    AK295250, AL591076, BC043414, DA205492, DA260869
    Consensus CDS
    CCDS69172.1
    UniProtKB/Swiss-Prot
    P46095
    Related
    ENSP00000406986.2, ENST00000414000.3
    Conserved Domains (1) summary
    cd15962
    Location:88355
    7tmA_GPR6; G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005284.5NP_005275.1  G-protein coupled receptor 6 isoform b

    See identical proteins and their annotated locations for NP_005275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL591076, BC043414, DA205492, DA260869
    Consensus CDS
    CCDS5079.1
    UniProtKB/Swiss-Prot
    P46095, Q5SYL0
    UniProtKB/TrEMBL
    F1DAM6
    Related
    ENSP00000275169.3, ENST00000275169.5
    Conserved Domains (1) summary
    cd15962
    Location:73340
    7tmA_GPR6; G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    109978311..109980720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    111156757..111159166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)