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STK32C serine/threonine kinase 32C [ Homo sapiens (human) ]

Gene ID: 282974, updated on 18-Aug-2020

Summary

Official Symbol
STK32Cprovided by HGNC
Official Full Name
serine/threonine kinase 32Cprovided by HGNC
Primary source
HGNC:HGNC:21332
See related
Ensembl:ENSG00000165752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKE; YANK3
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Broad expression in brain (RPKM 5.0), testis (RPKM 3.2) and 22 other tissues See more
Orthologs

Genomic context

See STK32C in Genome Data Viewer
Location:
10q26.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (132207482..132332559, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133996038..134145377, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene uncharacterized LOC105378567 Neighboring gene dihydropyrimidinase like 4 Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene leucine rich repeat containing 27 Neighboring gene PWWP domain containing 2B Neighboring gene uncharacterized LOC105378568

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 32C
Names
PKE protein kinase
testicular tissue protein Li 187
yet another novel kinase 3
NP_001305807.1
NP_001305808.1
NP_001305809.1
NP_001305810.1
NP_001305811.1
NP_001305812.1
NP_775846.2
XP_011537990.1
XP_011537992.1
XP_011537995.1
XP_011537996.1
XP_011537997.1
XP_011537998.1
XP_016871589.1
XP_016871590.1
XP_024303715.1
XP_024303716.1
XP_024303717.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318878.2NP_001305807.1  serine/threonine-protein kinase 32C isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK302102, AL590105, CD369442, HY020713, HY070240
    UniProtKB/TrEMBL
    B7Z7J1
    Conserved Domains (2) summary
    smart00220
    Location:106361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:105366
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  2. NM_001318879.2NP_001305808.1  serine/threonine-protein kinase 32C isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK302102, BC045760, CD369442, HY018020
    Consensus CDS
    CCDS81525.1
    UniProtKB/Swiss-Prot
    Q86UX6
    UniProtKB/TrEMBL
    B7Z7J1
    Related
    ENSP00000357611.1, ENST00000368622.5
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  3. NM_001318880.2NP_001305809.1  serine/threonine-protein kinase 32C isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AA782619, AL590105, CD674243, HY020713, HY070240
    Consensus CDS
    CCDS81527.1
    UniProtKB/TrEMBL
    H0Y431
    Related
    ENSP00000389112.2, ENST00000456004.1
  4. NM_001318881.2NP_001305810.1  serine/threonine-protein kinase 32C isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AL590105, AW770528, BE009030, BF508609, DA574949, HY020713
    Consensus CDS
    CCDS81526.1
    UniProtKB/TrEMBL
    H0Y349
    Related
    ENSP00000357608.4, ENST00000368619.3
  5. NM_001318882.2NP_001305811.1  serine/threonine-protein kinase 32C isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AI911241, AL590105, BF508609, HY020713, HY106710, HY301367
  6. NM_001318883.2NP_001305812.1  serine/threonine-protein kinase 32C isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon and lacks the remaining exons found in variant 1, but instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AL590105, BF449072, BF508609, HY020713
  7. NM_173575.4NP_775846.2  serine/threonine-protein kinase 32C isoform b

    See identical proteins and their annotated locations for NP_775846.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK302102, AY098866, CD369442
    Consensus CDS
    CCDS7666.1
    UniProtKB/Swiss-Prot
    Q86UX6
    UniProtKB/TrEMBL
    A0A140VJW0, B7Z7J1
    Related
    ENSP00000298630.3, ENST00000298630.8
    Conserved Domains (2) summary
    smart00220
    Location:93348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:92353
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

RNA

  1. NR_134911.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' terminal exon and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, which results in an ORF that is in-frame with the coding region of variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057849, AK302102, BM749615, CD369442
    Related
    ENST00000462160.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    132207482..132332559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539693.2XP_011537995.1  serine/threonine-protein kinase 32C isoform X3

    See identical proteins and their annotated locations for XP_011537995.1

    UniProtKB/Swiss-Prot
    Q86UX6
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  2. XM_011539688.1XP_011537990.1  serine/threonine-protein kinase 32C isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:106366
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:105371
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  3. XM_024447947.1XP_024303715.1  serine/threonine-protein kinase 32C isoform X3

    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  4. XM_011539690.2XP_011537992.1  serine/threonine-protein kinase 32C isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:93353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:92358
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  5. XM_024447948.1XP_024303716.1  serine/threonine-protein kinase 32C isoform X3

    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  6. XM_011539695.1XP_011537997.1  serine/threonine-protein kinase 32C isoform X3

    See identical proteins and their annotated locations for XP_011537997.1

    UniProtKB/Swiss-Prot
    Q86UX6
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  7. XM_011539696.1XP_011537998.1  serine/threonine-protein kinase 32C isoform X3

    See identical proteins and their annotated locations for XP_011537998.1

    UniProtKB/Swiss-Prot
    Q86UX6
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  8. XM_011539694.1XP_011537996.1  serine/threonine-protein kinase 32C isoform X3

    See identical proteins and their annotated locations for XP_011537996.1

    UniProtKB/Swiss-Prot
    Q86UX6
    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  9. XM_024447949.1XP_024303717.1  serine/threonine-protein kinase 32C isoform X3

    Conserved Domains (1) summary
    cd05578
    Location:1236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  10. XM_017016101.1XP_016871590.1  serine/threonine-protein kinase 32C isoform X5

  11. XM_017016100.1XP_016871589.1  serine/threonine-protein kinase 32C isoform X4

RNA

  1. XR_945687.2 RNA Sequence

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