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C10orf53 chromosome 10 open reading frame 53 [ Homo sapiens (human) ]

Gene ID: 282966, updated on 12-Oct-2019

Summary

Official Symbol
C10orf53provided by HGNC
Official Full Name
chromosome 10 open reading frame 53provided by HGNC
Primary source
HGNC:HGNC:27421
See related
Ensembl:ENSG00000178645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 9.4) See more
Orthologs

Genomic context

See C10orf53 in Genome Data Viewer
Location:
10q11.23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49679651..49710261)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50887684..50916956)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3429 Neighboring gene solute carrier family 18 member A3 Neighboring gene choline O-acetyltransferase Neighboring gene oxoglutarate dehydrogenase like Neighboring gene mitogen-activated protein kinase 6 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Potential readthrough

Included gene: CHAT

Homology

Clone Names

  • FLJ60598

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042427.3NP_001035892.1  UPF0728 protein C10orf53 isoform b

    See identical proteins and their annotated locations for NP_001035892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC073366
    Consensus CDS
    CCDS41521.1
    UniProtKB/Swiss-Prot
    Q8N6V4
    Related
    ENSP00000363225.3, ENST00000374111.8
    Conserved Domains (1) summary
    pfam15092
    Location:189
    UPF0728; uncharacterized protein family UPF0728
  2. NM_182554.4NP_872360.2  UPF0728 protein C10orf53 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC069546, AC073366
    Consensus CDS
    CCDS31202.1
    UniProtKB/Swiss-Prot
    Q8N6V4
    Related
    ENSP00000363226.3, ENST00000374112.7
    Conserved Domains (1) summary
    pfam15092
    Location:177
    UPF0728; uncharacterized protein family UPF0728

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49679651..49710261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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