U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cthrc1 collagen triple helix repeat containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 282836, updated on 23-Jul-2026
Official Symbol
Cthrc1provided by RGD
Official Full Name
collagen triple helix repeat containing 1provided by RGD
Primary source
RGD:628801
See related
Ensembl:ENSRNOG00000004578 AllianceGenome:RGD:628801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Wnt-protein binding activity; frizzled binding activity; and prostaglandin-endoperoxide synthase activity. Acts upstream of or within cell migration. Located in extracellular matrix. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human CTHRC1 (collagen triple helix repeat containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Lung (RPKM 46.1), Muscle (RPKM 36.6) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Cthrc1 in Genome Data Viewer
Location:
7q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (72007372..72017654)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (70122474..70132756)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479899 Neighboring gene solute carrier family 25 member 32 Neighboring gene DDB1 and CUL4 associated factor 13

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genetic Determinants of Cerebral Arterial Adaptation to Flow-loading. Abruzzo TA, et al. Curr Neurovasc Res, 2018. PMID 29998805
  2. Screening of differentially methylated genes in skeletal fluorosis of rats with different types and involvement of aberrant methylation of Cthrc1. Ding H, et al. Environ Pollut, 2023 Sep 1. PMID 37268221
  3. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. LeClair RJ, et al. Circ Res, 2007 Mar 30. PMID 17322174
  4. IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-κB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein. Tai Y, et al. Int Immunopharmacol, 2021 Dec. PMID 34688134
  5. Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Durmus T, et al. Gene Expr Patterns, 2006 Oct. PMID 16678498

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cthrc1 has role in bladder growth following denervation.
    Title: Array profiling reveals contribution of Cthrc1 to growth of the denervated rat urinary bladder.
  2. CTHRC1 downregulation suppresses IL-1beta-induced JNK1/2 activation.
    Title: CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling.
  3. Overexpression of CHTRC1 increased osteogenic differentiation of periodontal ligament stem cells, which could be abolished by TAZ siRNA.
    Title: CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ.
  4. Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen levels with potentially broad implications for cell metabolism and physiology.
    Title: Cthrc1, a novel circulating hormone regulating metabolism.
  5. Intracellular localization of Cthrc1 characterizes differentiated smooth muscle.
    Title: Intracellular localization of Cthrc1 characterizes differentiated smooth muscle.
  6. CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration.
    Title: Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration.
  7. Cthrc1 is a cell-type-specific inhibitor of transforming growth factor-beta, which in turn impacts collagen type I and III deposition, neointimal formation, and dedifferentiation of smooth muscle cells.
    Title: Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin-endoperoxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclooxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of planar polarity involved in neural tube closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification involved in bone remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
collagen triple helix repeat-containing protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271300.1 → NP_001258229.1  collagen triple helix repeat-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8L2Q207
    Conserved Domains (1) summary
    pfam01391
    Location:44 → 76
    Collagen; Collagen triple helix repeat (20 copies)

  2. NM_172333.2 → NP_758836.1  collagen triple helix repeat-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_758836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q8CG08
    UniProtKB/TrEMBL
    A0A8L2Q207
    Related
    ENSRNOP00000006142.3, ENSRNOT00000006142.5
    Conserved Domains (1) summary
    pfam01391
    Location:59 → 91
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    72007372..72017654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CG08.1 GenPept UniProtKB/Swiss-Prot:Q8CG08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools