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GPR4 G protein-coupled receptor 4 [ Homo sapiens (human) ]

Gene ID: 2828, updated on 6-Sep-2021

Summary

Official Symbol
GPR4provided by HGNC
Official Full Name
G protein-coupled receptor 4provided by HGNC
Primary source
HGNC:HGNC:4497
See related
Ensembl:ENSG00000177464 MIM:600551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR6C.l
Expression
Broad expression in fat (RPKM 4.0), lung (RPKM 2.3) and 22 other tissues See more
Orthologs
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Genomic context

See GPR4 in Genome Data Viewer
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45589764..45602212, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46093022..46105470, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985315 Neighboring gene vasodilator stimulated phosphoprotein Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3 Neighboring gene EMAP like 2 Neighboring gene EML2 antisense RNA 1 Neighboring gene microRNA 330

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis involved in wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerular mesangial cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vascular permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 4
Names
G-protein coupled receptor 19
G-protein coupled receptor 6C.l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005282.3NP_005273.1  G-protein coupled receptor 4

    See identical proteins and their annotated locations for NP_005273.1

    Status: VALIDATED

    Source sequence(s)
    AC011480, BC038450, BE669939, DA858082
    Consensus CDS
    CCDS12669.1
    UniProtKB/Swiss-Prot
    P46093
    Related
    ENSP00000319744.3, ENST00000323040.5
    Conserved Domains (1) summary
    cd15366
    Location:18297
    7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45589764..45602212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026607.2XP_016882096.1  G-protein coupled receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    P46093
    Conserved Domains (1) summary
    cd15366
    Location:18297
    7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017026608.1XP_016882097.1  G-protein coupled receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    P46093
    Conserved Domains (1) summary
    cd15366
    Location:18297
    7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
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