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OR51B5 olfactory receptor family 51 subfamily B member 5 [ Homo sapiens (human) ]

Gene ID: 282763, updated on 5-Jan-2022

Summary

Official Symbol
OR51B5provided by HGNC
Official Full Name
olfactory receptor family 51 subfamily B member 5provided by HGNC
Primary source
HGNC:HGNC:19599
See related
Ensembl:ENSG00000167355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-37; HOR5'Beta5
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OR51B5 in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (5340318..5505652, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5361548..5526882, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily B member 2 Neighboring gene olfactory receptor family 51 subfamily B member 8 pseudogene Neighboring gene amphiphysin pseudogene Neighboring gene transmembrane protein 258 pseudogene Neighboring gene olfactory receptor family 51 subfamily B member 6 Neighboring gene beta-globin hypersensitive site -107 Neighboring gene beta-globin hypersensitive site -111 Neighboring gene olfactory receptor family 51 subfamily M member 1 Neighboring gene olfactory receptor family 51 subfamily J member 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1 Neighboring gene olfactory receptor family 51 subfamily K member 1 pseudogene Neighboring gene olfactory receptor family 51 subfamily I member 1 Neighboring gene olfactory receptor family 51 subfamily I member 2 Neighboring gene olfactory receptor family 51 subfamily A member 10 pseudogene Neighboring gene olfactory receptor family 52 subfamily D member 1 Neighboring gene ubiquilin 3 Neighboring gene ubiquilin like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 51B5
Names
odorant receptor HOR5'beta5
olfactory receptor OR11-37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005567.3NP_001005567.2  olfactory receptor 51B5

    See identical proteins and their annotated locations for NP_001005567.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the olfactory receptor 51B5.
    Source sequence(s)
    AC087380, AC104389
    Consensus CDS
    CCDS31378.1
    UniProtKB/Swiss-Prot
    Q9H339
    UniProtKB/TrEMBL
    Q05CQ2
    Conserved Domains (1) summary
    cd15222
    Location:23297
    7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001395252.1NP_001382181.1  olfactory receptor 51B5

    Status: VALIDATED

    Source sequence(s)
    AC104389
    Related
    ENSP00000300773.2, ENST00000300773.3
    Conserved Domains (1) summary
    cd15222
    Location:23297
    7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_038321.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' exon and is a non-coding transcript compared to variant 1.
    Source sequence(s)
    AC104389, BG776801
    Related
    ENST00000415970.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    5340318..5505652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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