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GPR3 G protein-coupled receptor 3 [ Homo sapiens (human) ]

Gene ID: 2827, updated on 15-Apr-2019

Summary

Official Symbol
GPR3provided by HGNC
Official Full Name
G protein-coupled receptor 3provided by HGNC
Primary source
HGNC:HGNC:4484
See related
Ensembl:ENSG00000181773 MIM:600241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACCA
Summary
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
Expression
Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues See more
Orthologs

Genomic context

See GPR3 in Genome Data Viewer
Location:
1p36.11
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (27392644..27395814)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27719148..27722318)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ficolin 3 Neighboring gene CD164 molecule like 2 Neighboring gene WASP family member 2 Neighboring gene uncharacterized LOC105376892

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 3
Names
ACCA orphan receptor
adenylate cyclase constitutive activator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005281.4NP_005272.1  G-protein coupled receptor 3

    See identical proteins and their annotated locations for NP_005272.1

    Status: REVIEWED

    Source sequence(s)
    FO393419
    Consensus CDS
    CCDS303.1
    UniProtKB/Swiss-Prot
    P46089
    UniProtKB/TrEMBL
    F1DAM5
    Related
    ENSP00000363136.3, ENST00000374024.4
    Conserved Domains (2) summary
    cd14964
    Location:4367
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:41308
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    27392644..27395814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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