ANXA2 annexin A2 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: ANXA2
Gene description: annexin A2
See related: BGD:BT26634; EnsemblRapid:ENSBTAG00070013055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (49800141..49844615)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dephosphorylation of annexin A2 by protein phosphatase 1 regulates endothelial cell barrier.
Title: Dephosphorylation of annexin A2 by protein phosphatase 1 regulates endothelial cell barrier.
expression of AnxA2-Y23A inhibited the formation of lipid microdomains, whereas the expression of AnxA2-Y23E altered actin filaments associated with docked granules. These results suggest that phosphorylation/dephosphorylation switch at Tyr23 in AnxA2 is critical for calcium-regulated exocytosis in neuroendocrine cells.
Title: Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cells.
ClfA binds with AnnexinA2 and this interaction could mediate S. aureus invasion into bovine mammary epithelial cells.
Title: Clumping factor A of Staphylococcus aureus interacts with AnnexinA2 on mammary epithelial cells.
AnxA2 functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c/Cyclin D1 signaling pathway.
Title: Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites.
Title: Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.
Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle.
Title: Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.
Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.
Title: Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.
Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer) trophectoderm may be related to the frequent failures of NT pregnancies.
Title: Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.
The results showed that alkaline phosphatase (ALP) activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake.
Title: Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells.
annexin II binds to CEACAM1 in a breast neoplasm model
Title: CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH66139 (e-PCR)
- UniSTS:91065

ANXA2 (e-PCR)
- UniSTS:277973

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding involved in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info	PubMed
enables virion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: annexin A2

Names: PAP-IV; annexin II; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; placental anticoagulant protein IV; protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.