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IFNL3 interferon lambda 3 [ Homo sapiens (human) ]

Gene ID: 282617, updated on 4-Nov-2018

Summary

Official Symbol
IFNL3provided by HGNC
Official Full Name
interferon lambda 3provided by HGNC
Primary source
HGNC:HGNC:18365
See related
Ensembl:ENSG00000197110 MIM:607402; Vega:OTTHUMG00000182805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IFNL3 in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (39243606..39245077, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39734272..39735916, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene syncollin Neighboring gene interferon lambda 3 pseudogene 1 Neighboring gene interferon lambda 4 (gene/pseudogene) Neighboring gene methionine sulfoxide reductase B1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hepatitis c virus, susceptibility to
MedGen: C1835407 OMIM: 609532 GeneReviews: Not available
Compare labs
Peginterferon alfa-2a response
MedGen: CN184128 GeneReviews: Not available
Compare labs
Peginterferon alfa-2b response
MedGen: CN078000 GeneReviews: Not available
Compare labs
Ribavirin response
MedGen: CN184129 GeneReviews: Not available
not available
Simeprevir response
MedGen: CN236396 GeneReviews: Not available
not available
Telaprevir response
MedGen: CN078014 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
NHGRI GWA Catalog
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.
NHGRI GWA Catalog
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Type III interferon signaling, organism-specific biosystem (from WikiPathways)
    Type III interferon signaling, organism-specific biosystemThe recently identified type III interferon group consists of three IFN-? (lambda) genes encoding molecules called IFN-?1, IFN-?2 and IFN-?3 (also called IL29, IL28A and IL28B respectively). These IF...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interferon lambda-3
Names
cytokine Zcyto22
interferon, lambda 4
interleukin-28B
interleukin-28C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042193.1 RefSeqGene

    Range
    4966..6366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346937.1NP_001333866.1  interferon lambda-3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). This isoform does not contain a signal peptide, compared to isoform 2.
    Source sequence(s)
    AY129149, BC130316
    Consensus CDS
    CCDS86765.1
    UniProtKB/Swiss-Prot
    Q8IZI9
    UniProtKB/TrEMBL
    A0A0C4DGW8
    Related
    ENSP00000481633.1, ENST00000613087.4
  2. NM_172139.3NP_742151.2  interferon lambda-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_742151.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon resulting in a novel 5' UTR, and the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus, and contains a signal peptide, compared to isoform 1.
    Source sequence(s)
    BC130316
    Consensus CDS
    CCDS12530.1
    UniProtKB/Swiss-Prot
    Q8IZI9
    Related
    ENSP00000409000.2, OTTHUMP00000270255, ENST00000413851.2, OTTHUMT00000463832
    Conserved Domains (1) summary
    pfam15177
    Location:34192
    IL28A; Interleukin-28A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    39243606..39245077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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