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has3 hyaluronan synthase 3 [ Danio rerio (zebrafish) ]

Gene ID: 282555, updated on 9-Sep-2025
Official Symbol
has3provided by ZNC
Official Full Name
hyaluronan synthase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-021118-1
See related
Ensembl:ENSDARG00000057210 AllianceGenome:ZFIN:ZDB-GENE-021118-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dg42III; af190743gs2; xx:af190743gs1; xx:af190743gs2
Summary
Predicted to enable hyaluronan synthase activity. Predicted to be involved in extracellular matrix assembly; hyaluronan biosynthetic process; and polysaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hypochord; median fin fold; nervous system; otic vesicle; and pectoral fin. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See has3 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (18408127..18421400, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17024139..17037412, complement)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene si:ch211-218c6.8 Neighboring gene tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) Neighboring gene TBC1 domain family, member 15 Neighboring gene CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) Neighboring gene transport and golgi organization 6 homolog (Drosophila) Neighboring gene interleukin 17c

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Ancient origin of lubricated joints in bony vertebrates. Askary A, et al. Elife, 2016 Jul 19. PMID 27434666, Free PMC Article
  2. Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear. Mackowetzky K, et al. Dev Dyn, 2022 Nov. PMID 35710880
  3. Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Munjal A, et al. Cell, 2021 Dec 22. PMID 34942099, Free PMC Article
  4. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. Govindan J, et al. PLoS One, 2016. PMID 26828861, Free PMC Article
  5. Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis. Mori Y, et al. Development, 2025 Jan 1. PMID 39651757, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronan synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hyaluronan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hyaluronan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
hyaluronan synthase 3
NP_775327.2
XP_009291796.1
XP_068070811.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173220.2 → NP_775327.2  hyaluronan synthase 3

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000018
    UniProtKB/TrEMBL
    A0A8M1PDY9, Q1LUE8
    Related
    ENSDARP00000074268.3, ENSDART00000079817.5
    Conserved Domains (2) summary
    cd06434
    Location:82 → 364
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    TIGR04242
    Location:11 → 466
    nodulat_NodC; chitooligosaccharide synthase NodC

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    18408127..18421400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214710.1 → XP_068070811.1  hyaluronan synthase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M1PDY9, Q1LUE8

  2. XM_009293521.4 → XP_009291796.1  hyaluronan synthase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJI3
    Conserved Domains (2) summary
    cd06434
    Location:85 → 367
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    TIGR04242
    Location:14 → 469
    nodulat_NodC; chitooligosaccharide synthase NodC
Nucleotide Protein Strain
Heading Accession and Version

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