U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

drd3 dopamine receptor D3 [ Danio rerio (zebrafish) ]

Gene ID: 282554, updated on 9-Sep-2025
Official Symbol
drd3provided by ZNC
Official Full Name
dopamine receptor D3provided by ZNC
Primary source
ZFIN:ZDB-GENE-021119-1
See related
Ensembl:ENSDARG00000032131 AllianceGenome:ZFIN:ZDB-GENE-021119-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled dopamine receptor signaling pathway; negative regulation of glutamatergic synaptic transmission; and regulation of dopamine secretion. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See drd3 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 24 NC_133199.1 (24847110..24886341)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20967244..21006319)

Chromosome 24 - NC_133199.1Genomic Context describing neighboring genes Neighboring gene si:ch211-161h7.8 Neighboring gene karyopherin alpha 1 (importin alpha 5) Neighboring gene uncharacterized LOC137489235 Neighboring gene uncharacterized LOC141380673 Neighboring gene uncharacterized LOC141380674 Neighboring gene uncharacterized LOC137489288 Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Boehmler W, et al. Dev Dyn, 2004 Jul. PMID 15188433
  2. Dopamine Receptors Gene Expression Pattern and Locomotor Improvement Differ Between Female and Male Zebrafish During Spinal Cord Auto Repair. Hosseini P, et al. Zebrafish, 2022 Aug. PMID 35905303
  3. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. Hwang WY, et al. PLoS One, 2013. PMID 23874735, Free PMC Article
  4. Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model. Dongjie S, et al. Biomed Pharmacother, 2022 Apr. PMID 35152046
  5. Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease. Lv DJ, et al. Behav Brain Res, 2019 Oct 17. PMID 31195038

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The evolution and expression of derd3 were studied.
    Title: Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha2-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of amine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
D(3) dopamine receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183067.1 → NP_898890.1  D(3) dopamine receptor

    See identical proteins and their annotated locations for NP_898890.1

    Status: PROVISIONAL

    Source sequence(s)
    AY183455
    UniProtKB/TrEMBL
    Q8AWE1
    Related
    ENSDARP00000104546.1, ENSDART00000129675.2
    Conserved Domains (2) summary
    pfam00001
    Location:52 → 437
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:50 → 225
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133199.1 Reference GRCz12tu Primary Assembly

    Range
    24847110..24886341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073939989.1 → XP_073796090.1  D(3) dopamine receptor isoform X6

  2. XM_021470111.3 → XP_021325786.1  D(3) dopamine receptor isoform X2

    UniProtKB/TrEMBL
    A0A8M9PTW6
    Conserved Domains (2) summary
    cd14964
    Location:51 → 75
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:49 → 461
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_073939987.1 → XP_073796088.1  D(3) dopamine receptor isoform X4

  4. XM_068217028.2 → XP_068073129.1  D(3) dopamine receptor isoform X3

    UniProtKB/TrEMBL
    A0AB32TCS3

  5. XM_005162673.6 → XP_005162730.1  D(3) dopamine receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9M1, F1QG18
    Related
    ENSDARP00000109548.2
    Conserved Domains (2) summary
    pfam00001
    Location:70 → 455
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:68 → 243
    7tm_4; Olfactory receptor

  6. XM_073939988.1 → XP_073796089.1  D(3) dopamine receptor isoform X5

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools