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RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282516, updated on 5-Sep-2025
Official Symbol
RAP1GDS1provided by VGNC
Official Full Name
Rap1 GTPase-GDP dissociation stimulator 1provided by VGNC
Primary source
VGNC:VGNC:33718
See related
EnsemblRapid:ENSBTAG00070003211
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SmgGDS
Orthologs
human mouse all
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See RAP1GDS1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (26124918..26275603, complement)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tetraspanin 5 Neighboring gene uncharacterized LOC112447049 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132345483

Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins. Yamamoto T, et al. J Biol Chem, 1990 Sep 25. PMID 2118909
  2. Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Kaibuchi K, et al. Mol Cell Biol, 1991 May. PMID 1901951, Free PMC Article
  3. The stimulatory GDP/GTP exchange protein for ras p21-related small GTP-binding proteins. Yamamoto T. Kobe J Med Sci, 1992 Feb. PMID 1495270
  4. Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. Thill R, et al. J Cell Biochem, 2008 Aug 1. PMID 18348285
  5. Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6. Olsen HG, et al. Genetics, 2005 Jan. PMID 15466433, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.
    Title: Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC137736

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
rap1 GTPase-GDP dissociation stimulator 1
Names
RAP1, GTP-GDP dissociation stimulator 1
SMG GDS protein
SMG P21 stimulatory GDP/GTP exchange protein
exchange factor smgGDS

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174666.3 → NP_777091.2  rap1 GTPase-GDP dissociation stimulator 1

    See identical proteins and their annotated locations for NP_777091.2

    Status: PROVISIONAL

    Source sequence(s)
    BC112707
    UniProtKB/Swiss-Prot
    A0A3Q1M477, Q04173, Q9TS36
    UniProtKB/TrEMBL
    Q2KIA8
    Conserved Domains (4) summary
    smart00185
    Location:297 → 340
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:86 → 117
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:44 → 75
    ARM; armadillo repeat [structural motif]
    cl26969
    Location:177 → 342
    Vitellogenin_N; Lipoprotein amino terminal region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26124918..26275603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024993023.2 → XP_024848791.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A3Q1M477, Q04173, Q9TS36
    Related
    ENSBTAP00070004352.1, ENSBTAT00070007389.1
    Conserved Domains (5) summary
    smart00185
    Location:347 → 390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:86 → 117
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:91 → 116
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:86 → 192
    Arm_3; Atypical Arm repeat
    cl26969
    Location:227 → 392
    Vitellogenin_N; Lipoprotein amino terminal region

  2. XM_024993026.2 → XP_024848794.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X6

    UniProtKB/Swiss-Prot
    A0A3Q1M477, Q04173, Q9TS36
    Conserved Domains (4) summary
    smart00185
    Location:297 → 340
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:86 → 117
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:44 → 75
    ARM; armadillo repeat [structural motif]
    cl26969
    Location:177 → 342
    Vitellogenin_N; Lipoprotein amino terminal region

  3. XM_024993025.2 → XP_024848793.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1LS60, F6RPT3
    Related
    ENSBTAP00070004354.1, ENSBTAT00070007400.1
    Conserved Domains (3) summary
    smart00185
    Location:298 → 341
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:45 → 76
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:87 → 118
    Arm; Armadillo/beta-catenin-like repeat

  4. XM_024993024.2 → XP_024848792.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X3

    UniProtKB/TrEMBL
    F6RPT3
    Conserved Domains (5) summary
    smart00185
    Location:348 → 391
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:87 → 118
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:92 → 117
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:87 → 193
    Arm_3; Atypical Arm repeat
    cl26969
    Location:228 → 393
    Vitellogenin_N; Lipoprotein amino terminal region

  5. XM_024993022.2 → XP_024848790.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

    UniProtKB/TrEMBL
    F6RPT3
    Related
    ENSBTAP00070004349.1, ENSBTAT00070007374.1
    Conserved Domains (5) summary
    smart00185
    Location:348 → 391
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:87 → 118
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:92 → 117
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:87 → 193
    Arm_3; Atypical Arm repeat
    cl26969
    Location:228 → 393
    Vitellogenin_N; Lipoprotein amino terminal region

  6. XM_059887324.1 → XP_059743307.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X4

    UniProtKB/TrEMBL
    A0AAA9SW23
    Related
    ENSBTAP00070004350.1, ENSBTAT00070007384.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04173.2 GenPept UniProtKB/Swiss-Prot:Q04173

Gene LinkOut

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Molecular Biology Databases
Research Materials