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FAS Fas cell surface death receptor [ Bos taurus (domestic cattle) ]

Gene ID: 282488, updated on 5-Sep-2025
Official Symbol
FASprovided by VGNC
Official Full Name
Fas cell surface death receptorprovided by VGNC
Primary source
VGNC:VGNC:28869
See related
BGD:BT10380; EnsemblRapid:ENSBTAG00070026428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
APO1; TNFRSF6
Orthologs
human mouse all
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See FAS in Genome Data Viewer
Location:
chromosome: 26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (10678642..10745124)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene STAM binding protein like 1 Neighboring gene uncharacterized LOC132343936 Neighboring gene actin alpha 2, smooth muscle Neighboring gene uncharacterized LOC104975941 Neighboring gene cholesterol 25-hydroxylase

Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A possible role of Fas antigen in ejaculated spermatozoa of fertile bulls: an immunocytochemical quantitative approach. Meggiolaro D, et al. Acta Histochem, 2006. PMID 16330085
  2. Cloning and characterization of the bovine Fas. Yoo J, et al. DNA Cell Biol, 1996 Mar. PMID 8634151
  3. Role of Fas-mediated apoptosis and follicle-stimulating hormone on the developmental capacity of bovine cumulus oocyte complexes in vitro. Rubio Pomar FJ, et al. Biol Reprod, 2004 Sep. PMID 15128594
  4. Genomic organization and chromosomal mapping of the bovine Fas/APO-1 gene. Yoo J, et al. DNA Cell Biol, 1996 May. PMID 8924212
  5. Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines. Duncan A, et al. Reprod Biol Endocrinol, 2012 Oct 31. PMID 23113883, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
    Title: Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy.
  2. Results did not support that K8/K18 filaments influence the expression of Fas on the surface of luteal cells.
    Title: Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines.
  3. activation of the Fas pathway and presence of FSH during in vitro maturation increased the incidence of apoptosis in cumulus cells
    Title: Role of Fas-mediated apoptosis and follicle-stimulating hormone on the developmental capacity of bovine cumulus oocyte complexes in vitro.
  4. demonstrated for the first time that normal ejaculated spermatozoa express Fas antigen; data showed that a large percentage of normal ejaculated spermatozoa of fertile bulls are immunocytochemically positive for Fas
    Title: A possible role of Fas antigen in ejaculated spermatozoa of fertile bulls: an immunocytochemical quantitative approach.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in necroptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 6
Names
FASLG receptor
Fas (TNF receptor superfamily, member 6)
apo-1 antigen
apoptosis (APO-1) antigen 1 ( FAS ), member 6
apoptosis-mediating surface antigen FAS
tumor necrosis factor receptor superfamily, member 6

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174662.2 → NP_777087.1  tumor necrosis factor receptor superfamily member 6 precursor

    See identical proteins and their annotated locations for NP_777087.1

    Status: PROVISIONAL

    Source sequence(s)
    U34794
    UniProtKB/Swiss-Prot
    P51867
    UniProtKB/TrEMBL
    A0A3Q1MVY3
    Related
    ENSBTAP00070035497.1, ENSBTAT00070059819.1
    Conserved Domains (2) summary
    cd08316
    Location:218 → 307
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:36 → 163
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    10678642..10745124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059881738.1 → XP_059737721.1  tumor necrosis factor receptor superfamily member 6 isoform X4

  2. XM_059881736.1 → XP_059737719.1  tumor necrosis factor receptor superfamily member 6 isoform X2

  3. XM_059881737.1 → XP_059737720.1  tumor necrosis factor receptor superfamily member 6 isoform X3

  4. XM_059881735.1 → XP_059737718.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MVY3
    Related
    ENSBTAP00070035513.1, ENSBTAT00070059846.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51867.1 GenPept UniProtKB/Swiss-Prot:P51867

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials