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COL10A1 collagen type X alpha 1 chain [ Bos taurus (domestic cattle) ]

Gene ID: 282416, updated on 5-Sep-2025
Official Symbol
COL10A1provided by VGNC
Official Full Name
collagen type X alpha 1 chainprovided by VGNC
Primary source
VGNC:VGNC:27553
See related
BGD:BT11784; EnsemblRapid:ENSBTAG00070005345
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Try the new Transcripts and proteins table
See COL10A1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (34539788..34547373)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene TSPY like 4 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene fyn related Src family tyrosine kinase Neighboring gene uncharacterized LOC132346217 Neighboring gene uncharacterized LOC112448033

Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes. Thomas JT, et al. Biochem J, 1991 Jan 1. PMID 1703407, Free PMC Article
  2. A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo. Gebhard S, et al. Matrix Biol, 2004 Aug. PMID 15464363
  3. Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo. Schmidl M, et al. J Biol Chem, 2006 Oct 20. PMID 16905550
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.
    Title: A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.
  2. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation
    Title: Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
collagen alpha-1(X) chain
Names
collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia)
type X collagen alpha 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174634.1 → NP_777059.1  collagen alpha-1(X) chain precursor

    See identical proteins and their annotated locations for NP_777059.1

    Status: PROVISIONAL

    Source sequence(s)
    X53556
    UniProtKB/Swiss-Prot
    P23206
    UniProtKB/TrEMBL
    F1MZ30
    Related
    ENSBTAP00070006859.1, ENSBTAT00070012191.1
    Conserved Domains (2) summary
    smart00110
    Location:539 → 674
    C1Q; Complement component C1q domain
    pfam01391
    Location:299 → 358
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34539788..34547373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23206.1 GenPept UniProtKB/Swiss-Prot:P23206

Gene LinkOut

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Molecular Biology Databases
Research Materials