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ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [ Bos taurus (domestic cattle) ]

Gene ID: 282401, updated on 11-Jun-2025
Official Symbol
ADAMTS2provided by VGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 2provided by VGNC
Primary source
VGNC:VGNC:25624
See related
BGD:BT11061; EnsemblRapid:ENSBTAG00070006836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See ADAMTS2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (2015432..2260679)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS4, X isoform-like Neighboring gene microRNA mir-11986 Neighboring gene zinc finger protein 354C Neighboring gene U2 spliceosomal RNA Neighboring gene zinc finger protein 879

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components. Colige A, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122202, Free PMC Article
  2. Characterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen. Colige A, et al. J Biol Chem, 1995 Jul 14. PMID 7622483
  3. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. Fernandes RJ, et al. J Biol Chem, 2001 Aug 24. PMID 11408482
  4. Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V. Colige A, et al. J Biol Chem, 2005 Oct 14. PMID 16046392
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
    Title: Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 2
Names
ADAM-TS 2
ADAM-TS2
ADAMTS-2
PC I-NP
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
pNPI
procollagen I N-proteinase
procollagen I/II amino propeptide-processing enzyme
procollagen N-endopeptidase
NP_777056.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174631.2 → NP_777056.1  A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor

    See identical proteins and their annotated locations for NP_777056.1

    Status: PROVISIONAL

    Source sequence(s)
    X96389
    UniProtKB/Swiss-Prot
    P79331
    UniProtKB/TrEMBL
    A0AAF6Z0S6
    Related
    ENSBTAP00070008845.1, ENSBTAT00070015528.1
    Conserved Domains (5) summary
    smart00209
    Location:558 → 610
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:260 → 461
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:262 → 464
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:92 → 203
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:717 → 831
    ADAM_spacer1; ADAM-TS Spacer 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    2015432..2260679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79331.1 GenPept UniProtKB/Swiss-Prot:P79331

Gene LinkOut

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