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LOC282340 ribonuclease, RNase A family, 1 (pancreatic) [ Bos taurus (domestic cattle) ]

Gene ID: 282340, updated on 5-Sep-2025
Gene symbol
LOC282340
Gene description
ribonuclease, RNase A family, 1 (pancreatic)
See related
BGD:BT12112; EnsemblRapid:ENSBTAG00070036007
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
RAC2; RNS1; RNASE1
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Try the new Transcripts and proteins table
See LOC282340 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (26356008..26357591)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene ribonuclease 7 Neighboring gene uncharacterized LOC132346352 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene uncharacterized LOC132346353 Neighboring gene ribonuclease A family member k6 Neighboring gene epididymal secretory protein E3-beta pseudogene

Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Park C, et al. Biochemistry, 2001 Apr 24. PMID 11305910
  2. A phosphate-binding subsite in bovine pancreatic ribonuclease A can be converted into a very efficient catalytic site. Moussaoui M, et al. Protein Sci, 2007 Jan. PMID 17192592, Free PMC Article
  3. Increase of RNase a N-terminus polarity or C-terminus apolarity changes the two domains' propensity to swap and form the two dimeric conformers of the protein. Gotte G, et al. Biochemistry, 2006 Sep 12. PMID 16953565
  4. Sequential 1H-NMR assignment and solution structure of bovine pancreatic ribonuclease A. Rico M, et al. Eur J Biochem, 1989 Aug 15. PMID 2776756
  5. Impact of an easily reducible disulfide bond on the oxidative folding rate of multi-disulfide-containing proteins. Leung HJ, et al. J Pept Res, 2005 Jan. PMID 15686534

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thermal unfolding of ribonuclease A (RNase) was analyzed in various osmolyte solutions of glycine, proline, sarcosine, N,N-dimethylglycine, betaine, myo-inositol, taurine, and trimethylamine-N-oxide (TMAO).
    Title: Thermodynamic analysis of osmolyte effect on thermal stability of ribonuclease A in terms of water activity.
  2. investigation of structure/stability of native pancreatic RNase A compared to specific analogs: Results suggest that a reverse turn (Asn113-Pro114) exhibits great control over unfolding, conformational stability, and enzymatic activity of RNase A.
    Title: Protein prosthesis: β-peptides as reverse-turn surrogates.
  3. The initials steps of the molecular mechanism of Urea-RNase A interaction passes through the establishment of a three center four electron adduct.
    Title: Urea's effect on the ribonuclease A catalytic efficiency: a kinetic, 1H NMR and molecular orbital study.
  4. Inactivation and reactivation of ribonuclease A studied by computer simulation.
    Title: Inactivation and reactivation of ribonuclease A studied by computer simulation.
  5. Overexpression of bovine RNase in Toll-like receptor (TLR)7 transgenic mice results in reduction in splenomegaly, reduced numbers of activated B and T cells, fewer immune deposits in the kidney, reduced liver inflammation, and increased survival.
    Title: Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.
  6. Data show that Asp83 replaced by Glu in ribonuclease A resulted in a comparable stabilization.
    Title: Significant stabilization of ribonuclease A by additive effects.
  7. Effect of D-amino acids on the functional activity and conformational stability of ribonuclease-A
    Title: Effect of D-amino acids on the functional activity and conformational stability of ribonuclease-A.
  8. The study suggests that domain swapping occurs via a local high-energy fluctuation at the C-terminus.
    Title: Propensity for C-terminal domain swapping correlates with increased regional flexibility in the C-terminus of RNase A.
  9. Folding, quality control, and secretion of pancreatic ribonuclease in live cells.
    Title: Folding, quality control, and secretion of pancreatic ribonuclease in live cells.
  10. Hydrogen/deuterium (H/D) exchange of the RNase A C-dimer reveal that the H-bonds formed between the swapped C-terminal beta-strand and the other subunit are strong. Their rupture may be crucial for C-dimer dissociation.
    Title: Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers.
Submit: New GeneRIF Correction See all GeneRIFs (28)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ribonuclease pancreatic
Names
RNase 1
RNase A
ribonuclease A (pancreatic)
ribonuclease A C2
NP_001014408.2
XP_005211519.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014386.4 → NP_001014408.2  ribonuclease pancreatic precursor

    See identical proteins and their annotated locations for NP_001014408.2

    Status: PROVISIONAL

    Source sequence(s)
    BC149636
    UniProtKB/Swiss-Prot
    A6QPW8, P61823
    Conserved Domains (1) summary
    smart00092
    Location:27 → 150
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26356008..26357591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005211462.3 → XP_005211519.1  ribonuclease pancreatic isoform X1

    See identical proteins and their annotated locations for XP_005211519.1

    UniProtKB/Swiss-Prot
    A6QPW8, P61823
    Related
    ENSBTAP00070048873.1, ENSBTAT00070080713.1
    Conserved Domains (1) summary
    smart00092
    Location:27 → 150
    RNAse_Pc; Pancreatic ribonuclease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61823.1 GenPept UniProtKB/Swiss-Prot:P61823

Gene LinkOut

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Molecular Biology Databases
Research Materials