RNASE1 ribonuclease, RNase A family, 1 (pancreatic) [Bos taurus (cattle)] - Gene

Summary

Gene symbol: RNASE1
Gene description: ribonuclease, RNase A family, 1 (pancreatic)
See related: BGD:BT12112; EnsemblRapid:ENSBTAG00000008793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: RNS1
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	ARS-UCD1.2 (GCF_002263795.1)	10	NC_037337.1 (26356008..26357591)
105	previous assembly	Bos_taurus_UMD_3.1.1 (GCF_000003055.6)	10	AC_000167.1 (26388180..26389763)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thermal unfolding of ribonuclease A (RNase) was analyzed in various osmolyte solutions of glycine, proline, sarcosine, N,N-dimethylglycine, betaine, myo-inositol, taurine, and trimethylamine-N-oxide (TMAO).
Title: Thermodynamic analysis of osmolyte effect on thermal stability of ribonuclease A in terms of water activity.
investigation of structure/stability of native pancreatic RNase A compared to specific analogs: Results suggest that a reverse turn (Asn113-Pro114) exhibits great control over unfolding, conformational stability, and enzymatic activity of RNase A.
Title: Protein prosthesis: β-peptides as reverse-turn surrogates.
The initials steps of the molecular mechanism of Urea-RNase A interaction passes through the establishment of a three center four electron adduct.
Title: Urea's effect on the ribonuclease A catalytic efficiency: a kinetic, 1H NMR and molecular orbital study.
Inactivation and reactivation of ribonuclease A studied by computer simulation.
Title: Inactivation and reactivation of ribonuclease A studied by computer simulation.
Overexpression of bovine RNase in Toll-like receptor (TLR)7 transgenic mice results in reduction in splenomegaly, reduced numbers of activated B and T cells, fewer immune deposits in the kidney, reduced liver inflammation, and increased survival.
Title: Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.
Data show that Asp83 replaced by Glu in ribonuclease A resulted in a comparable stabilization.
Title: Significant stabilization of ribonuclease A by additive effects.
Effect of D-amino acids on the functional activity and conformational stability of ribonuclease-A
Title: Effect of D-amino acids on the functional activity and conformational stability of ribonuclease-A.
The study suggests that domain swapping occurs via a local high-energy fluctuation at the C-terminus.
Title: Propensity for C-terminal domain swapping correlates with increased regional flexibility in the C-terminus of RNase A.
Folding, quality control, and secretion of pancreatic ribonuclease in live cells.
Title: Folding, quality control, and secretion of pancreatic ribonuclease in live cells.
Hydrogen/deuterium (H/D) exchange of the RNase A C-dimer reveal that the H-bonds formed between the swapped C-terminal beta-strand and the other subunit are strong. Their rupture may be crucial for C-dimer dissociation.
Title: Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonuclease A activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease pancreatic

Names: RNase 1; RNase A; ribonuclease A (pancreatic)

NP_001014408.2

EC 4.6.1.18

XP_005211519.1

EC 4.6.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.