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SLCO3A1 solute carrier organic anion transporter family member 3A1 [ Homo sapiens (human) ]

Gene ID: 28232, updated on 3-Sep-2017
Official Symbol
SLCO3A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 3A1provided by HGNC
Primary source
HGNC:HGNC:10952
See related
Ensembl:ENSG00000176463 MIM:612435; Vega:OTTHUMG00000149846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATPD; OATP-D; OATP3A1; OATPRP3; OATP-RP3; SLC21A11
Orthologs
Location:
15q26.1
Exon count:
15
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (91853708..92172435)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (92396938..92715665)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene transfer RNA-Tyr (GTA) 12-1 Neighboring gene thyroid hormone receptor associated protein 3 pseudogene Neighboring gene uncharacterized LOC105370974 Neighboring gene uncharacterized LOC107984747 Neighboring gene uncharacterized LOC107987227 Neighboring gene double homeobox A pseudogene 6

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
NHGRI GWA Catalog
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
NHGRI GWA Catalog
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ40478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
prostaglandin transport IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier organic anion transporter family member 3A1
Names
PGE1 transporter
organic anion transporter polypeptide-related protein 3
organic anion-transporting polypeptide D
sodium-independent organic anion transporter D
solute carrier family 21 (organic anion transporter), member 11
solute carrier family 21 member 11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145044.1NP_001138516.1  solute carrier organic anion transporter family member 3A1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and contains an alternate 3' terminal exon compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC104020, AC113190, AC116903, AF205074, BC000585
    Consensus CDS
    CCDS45354.1
    UniProtKB/Swiss-Prot
    Q9UIG8
    Related
    ENSP00000387846.2, OTTHUMP00000246724, ENST00000424469.2, OTTHUMT00000414816
    Conserved Domains (3) summary
    cd06174
    Location:47286
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:467511
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:41619
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. NM_013272.3NP_037404.2  solute carrier organic anion transporter family member 3A1 isoform 1

    See identical proteins and their annotated locations for NP_037404.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104020, AC113190, AC116903, AF205074
    Consensus CDS
    CCDS10371.1
    UniProtKB/Swiss-Prot
    Q9UIG8
    Related
    ENSP00000320634.6, OTTHUMP00000194777, ENST00000318445.10, OTTHUMT00000313529
    Conserved Domains (3) summary
    cd06174
    Location:47286
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:467511
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:41619
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RNA

  1. NR_135775.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104236, AC113190, AK310306, DB508493, HY004505
    Related
    ENST00000555769.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

    Range
    91853708..92172435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254889.1XP_005254946.1  solute carrier organic anion transporter family member 3A1 isoform X1

    Conserved Domains (3) summary
    cd06174
    Location:47286
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:467511
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:41619
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. XM_005254891.2XP_005254948.1  solute carrier organic anion transporter family member 3A1 isoform X3

    Conserved Domains (3) summary
    cd06174
    Location:62171
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:352396
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:62504
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. XM_011521456.2XP_011519758.1  solute carrier organic anion transporter family member 3A1 isoform X2

    Conserved Domains (3) summary
    cd06174
    Location:4228
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:409453
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:3561
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RNA

  1. XR_931795.1 RNA Sequence

  2. XR_931796.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    92238177..92556655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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