POU5F1 POU class 5 homeobox 1 [Bos taurus (cattle)] - Gene

Summary

Gene symbol: POU5F1
Gene description: POU class 5 homeobox 1
See related: BGD:BT12336; Ensembl:ENSBTAG00000021111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: OCT3; OCT4; OTF-3; oct-3; oct-4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (27982798..27987297)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDX2 expression was aberrant in embryos lacking POU5F1
Title: Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation.
In OCT4 KO morulae (day 5), approximately 70% of the nuclei were OCT4 positive, indicating that maternal OCT4 mRNA partially maintains OCT4 protein expression during early development.
Title: OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.
The use of a clonal cell populations with low senescence level, normal karyotype, and highest POU5F1 expression levels did not improve embryo development rates or quality following SCNT. As previously suggested, this study supports the notion that levels of POU5F1 expression in the donor nucleus do not impact the Somatic cell nuclear transfer results.
Title: Effect of POU5F1 Expression Level in Clonal Subpopulations of Bovine Fibroblasts Used as Nuclear Donors for Somatic Cell Nuclear Transfer.
we concluded that OCT4 expression in somatic cells is not a good prognosis marker for selecting cell lines.
Title: Constitutive expression of the embryonic stem cell marker OCT4 in bovine somatic donor cells influences blastocysts rate and quality after nucleus transfer.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Title: Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo.
Oct4 exhibited significant hypermethylation in sperm compared with that in oocytes
Title: Methylation patterns in 5' terminal regions of pluripotency-related genes in mature bovine gametes.
The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.
Title: Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle.
analysis of CpG islands of bovine Leptin and POU5F1 genes in cloned bovine fetuses
Title: Epigenetic characterization of the CpG islands of bovine Leptin and POU5F1 genes in cloned bovine fetuses.
In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.
Title: Pluripotent lineage definition in bovine embryos by Oct4 transcript localization.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: POU domain, class 5, transcription factor 1

Names: Octamer-binding transcription factor 3; octamer transcription factor 4; octamer-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174580.3 → NP_777005.2 POU domain, class 5, transcription factor 1

Status: VALIDATED

Source sequence(s)

NKLS02000023

UniProtKB/Swiss-Prot

O97552

UniProtKB/TrEMBL

F1N017

Related

ENSBTAP00000028122.5, ENSBTAT00000028122.7

Conserved Domains (2) summary

smart00352
Location:138 → 212

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:233 → 286

Homeobox; Homeobox domain