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SLCO4A1 solute carrier organic anion transporter family member 4A1 [ Homo sapiens (human) ]

Gene ID: 28231, updated on 17-Sep-2024

Summary

Official Symbol
SLCO4A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 4A1provided by HGNC
Primary source
HGNC:HGNC:10953
See related
Ensembl:ENSG00000101187 MIM:612436; AllianceGenome:HGNC:10953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 2.4), endometrium (RPKM 1.6) and 23 other tissues See more
Orthologs
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Genomic context

See SLCO4A1 in Genome Data Viewer
Location:
20q13.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62642503..62690740)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64441223..64489475)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61273855..61303645)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61266847-61267348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61267349-61267848 Neighboring gene uncharacterized LOC124904949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61279493-61280066 Neighboring gene SLCO4A1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18213 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61302735-61303693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61314847-61315390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61315391-61315933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339152-61339665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339666-61340178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340388-61340934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340935-61341479 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61352726-61352918 Neighboring gene neurotensin receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61354746-61355285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61366135-61366980 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:61371112-61372311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61392433-61393212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61400285-61401016 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61407515-61407676 Neighboring gene long intergenic non-protein coding RNA 659

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLCO4A1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier organic anion transporter family member 4A1
Names
OATP-RP1
colon organic anion transporter
organic anion transporter polypeptide-related protein 1
organic anion transporting polypeptide E
sodium-independent organic anion transporter E
solute carrier family 21 (organic anion transporter), member 12
solute carrier family 21 member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016354.4NP_057438.3  solute carrier organic anion transporter family member 4A1

    See identical proteins and their annotated locations for NP_057438.3

    Status: VALIDATED

    Source sequence(s)
    AB031051, AF205072, AI660559, BC015727, BM846201
    Consensus CDS
    CCDS13501.1
    UniProtKB/Swiss-Prot
    Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
    Related
    ENSP00000217159.1, ENST00000217159.6
    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62642503..62690740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260203.4XP_005260260.1  solute carrier organic anion transporter family member 4A1 isoform X3

    UniProtKB/TrEMBL
    E1P5H9, H0UI88
    Related
    ENSP00000434245.1, ENST00000497209.5
    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. XM_011528792.4XP_011527094.1  solute carrier organic anion transporter family member 4A1 isoform X1

    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. XM_017027827.3XP_016883316.1  solute carrier organic anion transporter family member 4A1 isoform X2

  4. XM_047440126.1XP_047296082.1  solute carrier organic anion transporter family member 4A1 isoform X4

RNA

  1. XR_001754251.3 RNA Sequence

  2. XR_007067450.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64441223..64489475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323385.1XP_054179360.1  solute carrier organic anion transporter family member 4A1 isoform X3

    UniProtKB/TrEMBL
    E1P5H9, H0UI88
  2. XM_054323380.1XP_054179355.1  solute carrier organic anion transporter family member 4A1 isoform X1

  3. XM_054323383.1XP_054179358.1  solute carrier organic anion transporter family member 4A1 isoform X2

  4. XM_054323387.1XP_054179362.1  solute carrier organic anion transporter family member 4A1 isoform X4

  5. XM_054323382.1XP_054179357.1  solute carrier organic anion transporter family member 4A1 isoform X5

    UniProtKB/Swiss-Prot
    Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
  6. XM_054323384.1XP_054179359.1  solute carrier organic anion transporter family member 4A1 isoform X2

  7. XM_054323386.1XP_054179361.1  solute carrier organic anion transporter family member 4A1 isoform X3

    UniProtKB/TrEMBL
    E1P5H9, H0UI88
  8. XM_054323381.1XP_054179356.1  solute carrier organic anion transporter family member 4A1 isoform X1

RNA

  1. XR_008485252.1 RNA Sequence

  2. XR_008485253.1 RNA Sequence