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SLCO4A1 solute carrier organic anion transporter family member 4A1 [ Homo sapiens (human) ]

Gene ID: 28231, updated on 15-Sep-2017
Official Symbol
SLCO4A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 4A1provided by HGNC
Primary source
HGNC:HGNC:10953
See related
Ensembl:ENSG00000101187 MIM:612436; Vega:OTTHUMG00000032923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12
Orthologs
Location:
20q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (62642445..62690700)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61273795..61317137)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 3 Neighboring gene uncharacterized WI2-87327B8.2 Neighboring gene uncharacterized LOC101928465 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene uncharacterized LOC107987285 Neighboring gene neurotensin receptor 1 Neighboring gene uncharacterized LOC107985428 Neighboring gene long intergenic non-protein coding RNA 659

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLCO4A1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
thyroid hormone transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
thyroid hormone transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transport TAS
Traceable Author Statement
more info
 
thyroid hormone transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier organic anion transporter family member 4A1
Names
OATP-RP1
colon organic anion transporter
organic anion transporter polypeptide-related protein 1
organic anion transporting polypeptide E
sodium-independent organic anion transporter E
solute carrier family 21 (organic anion transporter), member 12
solute carrier family 21 member 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016354.3NP_057438.3  solute carrier organic anion transporter family member 4A1

    See identical proteins and their annotated locations for NP_057438.3

    Status: VALIDATED

    Source sequence(s)
    AB031051, AF205072, AI660559, BC015727, BM846201
    Consensus CDS
    CCDS13501.1
    UniProtKB/Swiss-Prot
    Q96BD0
    Related
    ENSP00000217159.1, ENST00000217159.5
    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    62642445..62690700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260203.2XP_005260260.1  solute carrier organic anion transporter family member 4A1 isoform X3

    Related
    ENSP00000434245.1, OTTHUMP00000031492, ENST00000497209.5, OTTHUMT00000080047
    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. XM_011528792.2XP_011527094.1  solute carrier organic anion transporter family member 4A1 isoform X1

    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. XM_017027827.1XP_016883316.1  solute carrier organic anion transporter family member 4A1 isoform X2

  4. XM_017027826.1XP_016883315.1  solute carrier organic anion transporter family member 4A1 isoform X1

    Conserved Domains (3) summary
    cd06174
    Location:106489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106663
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RNA

  1. XR_001754255.1 RNA Sequence

  2. XR_001754251.1 RNA Sequence

  3. XR_001754257.1 RNA Sequence

  4. XR_001754254.1 RNA Sequence

  5. XR_001754258.1 RNA Sequence

  6. XR_936524.1 RNA Sequence

  7. XR_001754249.1 RNA Sequence

  8. XR_244116.3 RNA Sequence

  9. XR_001754253.1 RNA Sequence

  10. XR_244115.3 RNA Sequence

  11. XR_001754256.1 RNA Sequence

  12. XR_001754250.1 RNA Sequence

  13. XR_001754252.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    61174804..61204654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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