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PDGFRA platelet derived growth factor receptor alpha [ Bos taurus (domestic cattle) ]

Gene ID: 282301, updated on 30-Jan-2025
Official Symbol
PDGFRAprovided by VGNC
Official Full Name
platelet derived growth factor receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:32692
See related
BGD:BT24549; EnsemblRapid:ENSBTAG00070002454
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See PDGFRA in Genome Data Viewer
Location:
chromosome: 6
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (69723776..69771549)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene cysteine rich hydrophobic domain 2 Neighboring gene uncharacterized LOC112447080 Neighboring gene GS homeobox 2 Neighboring gene oligosaccharyltransferase complex subunit OSTC-like Neighboring gene U6 spliceosomal RNA

Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis. Ren L, et al. Genes (Basel), 2020 May 29. PMID 32485948, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis.
    Title: A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
platelet-derived growth factor receptor alpha
Names
platelet-derived growth factor receptor, alpha polypeptide
NP_001179274.1
XP_005208001.1
XP_010804424.1
XP_059743304.1
XP_059743305.1
XP_059743306.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192345.3 → NP_001179274.1  platelet-derived growth factor receptor alpha precursor

    See identical proteins and their annotated locations for NP_001179274.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000006
    UniProtKB/TrEMBL
    F1MX49
    Conserved Domains (5) summary
    cd04972
    Location:415 → 497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313 → 413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05105
    Location:555 → 956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28 → 100
    Ig_3; Immunoglobulin domain
    cl11960
    Location:228 → 311
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    69723776..69771549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059887321.1 → XP_059743304.1  platelet-derived growth factor receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q1ME99

  2. XM_010806122.3 → XP_010804424.1  platelet-derived growth factor receptor alpha isoform X2

    See identical proteins and their annotated locations for XP_010804424.1

    UniProtKB/TrEMBL
    F1MX49
    Related
    ENSBTAP00070003327.1, ENSBTAT00070005717.1
    Conserved Domains (5) summary
    cd04972
    Location:415 → 497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313 → 413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05105
    Location:555 → 956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28 → 100
    Ig_3; Immunoglobulin domain
    cl11960
    Location:228 → 311
    Ig; Immunoglobulin domain

  3. XM_059887322.1 → XP_059743305.1  platelet-derived growth factor receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q1ME99
    Related
    ENSBTAP00070003321.1, ENSBTAT00070005711.1

  4. XM_005207944.5 → XP_005208001.1  platelet-derived growth factor receptor alpha isoform X2

    See identical proteins and their annotated locations for XP_005208001.1

    UniProtKB/TrEMBL
    F1MX49
    Conserved Domains (5) summary
    cd04972
    Location:415 → 497
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05859
    Location:313 → 413
    Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
    cd05105
    Location:555 → 956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    pfam13927
    Location:28 → 100
    Ig_3; Immunoglobulin domain
    cl11960
    Location:228 → 311
    Ig; Immunoglobulin domain

  5. XM_059887323.1 → XP_059743306.1  platelet-derived growth factor receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q1ME99
Nucleotide Protein Strain
Heading Accession and Version

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