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PPP2R3B protein phosphatase 2 regulatory subunit B''beta [ Homo sapiens (human) ]

Gene ID: 28227, updated on 24-Nov-2020

Summary

Official Symbol
PPP2R3Bprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B''betaprovided by HGNC
Primary source
HGNC:HGNC:13417
See related
Ensembl:ENSG00000167393 MIM:300339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR48; PR70; NYREN8; PPP2R3L; PPP2R3LY
Summary
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
Expression
Broad expression in heart (RPKM 9.0), testis (RPKM 5.0) and 23 other tissues See more
Orthologs

Genomic context

See PPP2R3B in Genome Data Viewer
Location:
X;Y
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (333933..387327, complement)
109.20201120 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (333933..387327, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (294668..347690, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (244668..297690, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 1 Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene uncharacterized LOC102724521 Neighboring gene CNE-5 enhancer upstream of SHOX Neighboring gene CNE-3 enhancer upstream of SHOX

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 1 Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene uncharacterized LOC102724521 Neighboring gene CNE-5 enhancer upstream of SHOX Neighboring gene CNE-3 enhancer upstream of SHOX

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ60425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Names
NY-REN-8 antigen
protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta
protein phosphatase 2, regulatory subunit B'', beta
serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013257.1 RefSeqGene

    Range
    4986..57960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013239.5NP_037371.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

    See identical proteins and their annotated locations for NP_037371.2

    Status: REVIEWED

    Source sequence(s)
    AL954664, BK000521, BM666129, BM715684, DA061573
    Consensus CDS
    CCDS14104.1
    UniProtKB/Swiss-Prot
    Q9Y5P8
    Related
    ENSP00000375080.3, ENST00000390665.9
    Conserved Domains (1) summary
    pfam13499
    Location:319417
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    333933..387327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546177.3XP_011544479.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011544479.1

    Conserved Domains (1) summary
    pfam13499
    Location:319417
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_002958773.1 RNA Sequence

  2. XR_002958772.1 RNA Sequence

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    333933..387327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545630.3XP_011543932.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011543932.1

    Conserved Domains (1) summary
    pfam13499
    Location:319417
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_002958830.1 RNA Sequence

  2. XR_002958829.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187634.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    17129..70260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187667.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    6753..59400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199326.1: Suppressed sequence

    Description
    NM_199326.1: This RefSeq was permanently suppressed because the CDS was partial, and the transcript retains intronic sequence.
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