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IGFBP2 insulin like growth factor binding protein 2 [ Bos taurus (domestic cattle) ]

Gene ID: 282260, updated on 30-Jan-2025
Official Symbol
IGFBP2provided by VGNC
Official Full Name
insulin like growth factor binding protein 2provided by VGNC
Primary source
VGNC:VGNC:30084
See related
BGD:BT10909; EnsemblRapid:ENSBTAG00070001713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See IGFBP2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (104619962..104648632)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 Neighboring gene ribosomal protein L37a Neighboring gene insulin like growth factor binding protein 5 Neighboring gene transfer RNA serine (anticodon GGA)

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Associations between bovine IGFBP2 polymorphisms with fertility, milk production, and metabolic status in UK dairy cows. Clempson AM, et al. Anim Biotechnol, 2012 Apr. PMID 22537059
  2. Alanine screening mutagenesis establishes tyrosine 60 of bovine insulin-like growth factor binding protein-2 as a determinant of insulin-like growth factor binding. Hobba GD, et al. J Biol Chem, 1998 Jul 31. PMID 9677398
  3. The bovine insulin-like growth factor (IGF) binding protein purified from conditioned medium requires the N-terminal tripeptide in IGF-1 for binding. Szabo L, et al. Biochem Biophys Res Commun, 1988 Feb 29. PMID 2450535
  4. Characterization and cloning of a bovine insulin-like growth factor-binding protein. Upton FZ, et al. J Mol Endocrinol, 1990 Aug. PMID 1697752
  5. Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1. Bourner MJ, et al. J Cell Biochem, 1992 Feb. PMID 1377702

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Five novel SNPs were identified in IGFBP2, two of which had significant associations with fertility (age at conception in heifers and commencement of luteal activity) and 305-day milk yield in lactation 1.
    Title: Associations between bovine IGFBP2 polymorphisms with fertility, milk production, and metabolic status in UK dairy cows.
  2. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.
    Title: Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.
  3. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation
    Title: Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation.
  4. spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
    Title: Insulin-like growth factor-I and binding proteins 1, 2, and 3 in bovine nuclear transfer pregnancies.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor II binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
insulin-like growth factor-binding protein 2
Names
IBP-2
IGF-binding protein 2
IGFBP-2
insulin-like growth factor binding protein 2, 36kDa

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174555.1 → NP_776980.1  insulin-like growth factor-binding protein 2 precursor

    See identical proteins and their annotated locations for NP_776980.1

    Status: PROVISIONAL

    Source sequence(s)
    AF074854
    UniProtKB/Swiss-Prot
    O97599, P13384
    UniProtKB/TrEMBL
    A0AAF6YNV3
    Related
    ENSBTAP00070002216.1, ENSBTAT00070003979.1
    Conserved Domains (2) summary
    smart00121
    Location:37 → 124
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:219 → 298
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    104619962..104648632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13384.2 GenPept UniProtKB/Swiss-Prot:P13384

Gene LinkOut

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