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DNASE1 deoxyribonuclease 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282217, updated on 5-Sep-2025
Official Symbol
DNASE1provided by VGNC
Official Full Name
deoxyribonuclease 1provided by VGNC
Primary source
VGNC:VGNC:28132
See related
BGD:BT26610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See DNASE1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (2981353..2999607)

Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain containing 3 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene microRNA mir-2383 Neighboring gene TNF receptor associated protein 1 Neighboring gene uncharacterized LOC101903988 Neighboring gene CREB binding protein

Genomic Sequence:
NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cloning, sequencing and expression of a cDNA encoding bovine pancreatic deoxyribonuclease I in Escherichia coli: purification and characterization of the recombinant enzyme. Chen CY, et al. Gene, 1998 Jan 12. PMID 9469931
  2. Bovine pancreatic deoxyribonuclease A. Isolation of cyanogen bromide peptides; complete covalent structure of the polypeptide chain. Liao TH, et al. J Biol Chem, 1992 Apr 15. PMID 1348510
  3. X-ray structure of the DNase I-d(GGTATACC)2 complex at 2.3 A resolution. Weston SA, et al. J Mol Biol, 1992 Aug 20. PMID 1518054
  4. Structure refined to 2A of a nicked DNA octanucleotide complex with DNase I. Suck D, et al. Nature, 1988 Mar 31. PMID 3352748
  5. Crystallographic refinement and structure of DNase I at 2 A resolution. Oefner C, et al. J Mol Biol, 1986 Dec 5. PMID 3560229

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ascorbic acid has the ability to inhibit DNase I, one of the main endonucleases involved in DNA fragmentation during apoptosis.
    Title: Ascorbic acid as DNase I inhibitor in prevention of male infertility.
  2. the practical capability of this assay system was successfully demonstrated by its use to determine DNase I activity in bovine urine.
    Title: A label-free fluorescent assay for deoxyribonuclease I activity based on DNA-templated silver nanocluster/graphene oxide nanocomposite.
  3. Specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes.
    Title: Sequence-dependent DNA flexibility mediates DNase I cleavage.
  4. results indicated that the backbone hydrogen bonding in the antiparallel beta-sheet formed by its N- and C-termini, rather than the side-chain interactions, is crucial for the correct protein folding
    Title: Involvement of the N- and C-terminal fragments of bovine pancreatic deoxyribonuclease in active protein folding.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables deoxyribonuclease I activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
deoxyribonuclease-1
Names
DNase I
deoxyribonuclease I
NP_776959.1
XP_024840423.1
XP_024840425.1
XP_024840426.1
XP_024840427.1
XP_059737140.1
XP_059737141.1
XP_059737142.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174534.2 → NP_776959.1  deoxyribonuclease-1 precursor

    See identical proteins and their annotated locations for NP_776959.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ001538
    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63
    Conserved Domains (1) summary
    smart00476
    Location:24 → 282
    DNaseIc; deoxyribonuclease I

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    2981353..2999607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059881158.1 → XP_059737141.1  deoxyribonuclease-1 isoform X1

    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63

  2. XM_024984657.2 → XP_024840425.1  deoxyribonuclease-1 isoform X1

    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63
    Conserved Domains (1) summary
    smart00476
    Location:24 → 282
    DNaseIc; deoxyribonuclease I

  3. XM_059881157.1 → XP_059737140.1  deoxyribonuclease-1 isoform X1

    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63

  4. XM_059881159.1 → XP_059737142.1  deoxyribonuclease-1 isoform X2

  5. XM_024984658.2 → XP_024840426.1  deoxyribonuclease-1 isoform X1

    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63
    Conserved Domains (1) summary
    smart00476
    Location:24 → 282
    DNaseIc; deoxyribonuclease I

  6. XM_024984659.2 → XP_024840427.1  deoxyribonuclease-1 isoform X1

    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63
    Conserved Domains (1) summary
    smart00476
    Location:24 → 282
    DNaseIc; deoxyribonuclease I

  7. XM_024984655.2 → XP_024840423.1  deoxyribonuclease-1 isoform X1

    UniProtKB/Swiss-Prot
    A5PK44, P00639, Q8MJ27
    UniProtKB/TrEMBL
    Q9GL62, Q9GL63
    Conserved Domains (1) summary
    smart00476
    Location:24 → 282
    DNaseIc; deoxyribonuclease I
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00639.3 GenPept UniProtKB/Swiss-Prot:P00639

Gene LinkOut

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