ANGPT1 angiopoietin 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ANGPT1provided by VGNC
Official Full Name: angiopoietin 1provided by VGNC
Primary source: VGNC:VGNC:53848
See related: BGD:BT17993; EnsemblRapid:ENSBTAG00070005623
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	14	NC_037341.1 (56815170..57287107)

Chromosome 14 - NC_037341.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
Title: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF-stimulated endothelial permeability by Ang-1.
Title: Phosphorylation of endothelial nitric oxide synthase by atypical PKC zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro.
ANPT-1 becomes predominant in the follicle producing high levels of E(2), indicating the possible switch-over from ANPT-2 (antagonist) to ANPT-1 (agonist).
Title: Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows.

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General gene information

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Markers

Angpt1 (e-PCR), detects polymorphism
- UniSTS:498721

ANGPT1 (e-PCR)
- UniSTS:277969

Agpt (e-PCR), detects polymorphism
- UniSTS:166624

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Tie signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: angiopoietin-1

Names: ANG-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076797.1 → NP_001070265.1 angiopoietin-1 precursor

See identical proteins and their annotated locations for NP_001070265.1

Status: PROVISIONAL

Source sequence(s)

BC123628

UniProtKB/Swiss-Prot

O18920, Q08DP8

UniProtKB/TrEMBL

A0AAF6YZE8

Related

ENSBTAP00070007380.1, ENSBTAT00070012881.1

Conserved Domains (2) summary

cd00087
Location:280 → 495

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

TIGR04523
Location:80 → 258

Mplasa_alph_rch; helix-rich Mycoplasma protein