U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACVR2B activin A receptor type 2B [ Bos taurus (domestic cattle) ]

Gene ID: 282131, updated on 5-Sep-2025
Official Symbol
ACVR2Bprovided by VGNC
Official Full Name
activin A receptor type 2Bprovided by VGNC
Primary source
VGNC:VGNC:25596
See related
BGD:BT11072; EnsemblRapid:ENSBTAG00070023982
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ActRIIB; ActR-IIB
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ACVR2B in Genome Data Viewer
Location:
chromosome: 22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (11825975..11855764)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 14 Neighboring gene xylulokinase Neighboring gene exo/endonuclease G Neighboring gene sodium voltage-gated channel alpha subunit 5 Neighboring gene U6 spliceosomal RNA

Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Bovine activin receptor type IIB messenger ribonucleic acid displays alternative splicing involving a sequence homologous to Src-homology 3 domain binding sites. Ethier JF, et al. Endocrinology, 1997 Jun. PMID 9165032
  2. Expression of bone morphogenetic protein2 (BMP2), BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development. Fatehi AN, et al. Theriogenology, 2005 Feb. PMID 15629804
  3. Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors. Maruotti J, et al. Mol Reprod Dev, 2012 Jul. PMID 22573702
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
activin receptor type-2B
Names
activin A receptor, type IIB
activin receptor type IIB
NP_776920.1
XP_059735441.1
XP_059735442.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174495.2 → NP_776920.1  activin receptor type-2B precursor

    See identical proteins and their annotated locations for NP_776920.1

    Status: PROVISIONAL

    Source sequence(s)
    U57707
    UniProtKB/Swiss-Prot
    Q95126
    UniProtKB/TrEMBL
    A0A3Q1N4Z4
    Related
    ENSBTAP00070032389.1, ENSBTAT00070054014.1
    Conserved Domains (3) summary
    smart00220
    Location:198 → 471
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14140
    Location:194 → 484
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam01064
    Location:39 → 117
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    11825975..11855764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059879458.1 → XP_059735441.1  activin receptor type-2B isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MGJ6, A0A3Q1N4Z4

  2. XM_059879459.1 → XP_059735442.1  activin receptor type-2B isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95126.1 GenPept UniProtKB/Swiss-Prot:Q95126

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.